Was DES much used in the UK in the 1970s and before, as a treatment for miscarriage? It's not something I've seen discussed much here, but I know US women's health advocates were very aware of it. DES daughters are known to have fertility problems, and DES sons may exhibit AGF at a higher rate than others. The hormone is also linked to disorders of sexual development generally, as well as brain changes.
desdaughter.com/2014/03/01/the-link-between-des-exposure-and-mtf-transsexuality/
There seem to be very high rates of gender-related psychological problems too, to the point where quite a few of the DES sons I’ve chatted with online over the last year identify fully as women and have undergone reassignment
desinfo411.wordpress.com/2013/01/19/des-son-speaks-about-damage-keeplillyhonest/