Men have a higher risk of death from brain tumors: Scientists discover key gender difference

[TimeLady]

Co-senior author Dr Rosy Luo, also of Washington University, said: 'We observed tremendous genetic sex differences in the tumors of glioblastoma patients that correlated with survival.
'All evidence supports the need to define these distinctions and incorporate the sex differences into glioblastoma biology research and treatment.'
Specifically the tumors clustered into 10 distinct subtypes - five each for males and females - and distinguished by both gene activity and survival.

www.dailymail.co.uk/health/article-6548235/Men-higher-risk-death-brain-tumors-study-finds.html

And this is why it's important to keep the sex-category on records accurate.

sex sex sex
just use the word, not gender if that's not what you mean

Gosh. My mum died of glioblastoma last year. Is there a link to the research? I don't click on DM links.

When you’re talking about science you need to use the correct terminology.

The thread title is the deadline from the DM, which does use gender where they mean sex. The scientists quoted in the article use sex and sex differences.

It was in the Science Translational Medicine journal, apparently. Professor Joshua Rubin and Dr Rosy Luo.

I very much doubt that it's the medical team that are the ones mixing up sex with gender.

*headline, not deadline!

Thanks for that Timelady. Here's the paper if anyone's interested:

stm.sciencemag.org/content/11/473/eaao5253

181 mentions of 'sex' in the paper, and zero of 'gender' according to my browser:

"Sex differences in the incidence and outcome of human disease are broadly recognized but, in most cases, not sufficiently understood to enable sex-specific approaches to treatment."

Thanks for the direct link, ValWiggin

Interesting statement jumped out at me on the first page

Identifying the basis for sex differences in cancer biology cannot be accomplished by analysis of merged male and female datasets. Instead, it requires comparison of results from parallel analyses of male and female data.

Take note, Penny Mordaunt, et al.

Also from the original paper:

Current epidemiological data indicate that sex differences exist in the incidence of cardiovascular disease, disorders of the immune system, depression, addiction, asthma, and cancers (1–4), including glioblastoma (GBM) (5). Although sex differences in disease incidence and severity may parallel variation in circulating sex hormone concentrations, in many cases, sex differences exist across all stages of life, indicating some independence from acute hormone action (3, 6). Sex differences in GBM are evident in all age groups and therefore cannot be solely the consequence of activational effects of sex hormones (5, 7–11). Enumerating the molecular bases for sex differences in GBM is likely to reveal fundamental modulators of cancer risk and outcome as well as guide sex-specific components of precision medicine approaches to cancer treatment.

So not the same, and not just because of hormones.

And no sign of a sex spectrum (obviously!) ...

@Aspie: I thought all that was well known, about sex differences and medical conditions?

Well known but not always acknowledged.