Lupron and GnRH agonists getting attention finally

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khn.org/news/women-fear-drug-they-used-to-halt-puberty-led-to-health-problems/

Kaiser Health News

www.hormonesmatter.com/lupron-precocious-puberty-parents-patients-speak/
Hormone Matters website she also has a facebook page called "No Puberty Blockers for Children"

Long overdue. I'm thinking of this as mass hysteria like Tulipmania or the Dancing Plague. Eventually people will wake up and think WTF were we thinking? I hope so, anyway. The tragedy is that there will be some very damaged children and young people whose lives can never be what they should have been.

How authoritative are these websites, does anyone know?

There is a massive amount of information collected on this website.

www.lupronvictimshub.com

It is hair raising that children are being prescribed these dangerous drugs and their parents are being told they are totally risk free and completely reversible.

Kaiser Health News is legit. It is associated with, but editorially independent from, the Kaiser Family Foundation. The Foundation is a non-profit focused on health policy.

Is Lupron actually the blocker used in the UK for gender identity cases, though, or is it a different GnRH agonist?

Long overdue. I'm thinking of this as mass hysteria like Tulipmania or the Dancing Plague.

YY.

How authoritative are these websites, does anyone know?

It is the newsletter for the Kaiser Family Foundation, whose focus is on health policy research, analysis, polling, data and journalism. I don't know much about them other than this:

en.wikipedia.org/wiki/Kaiser_Family_Foundation

I think this is the drug used in the UK.
bnf.nice.org.uk/drug/triptorelin.html

Not to be confused with: Kaiser Permanente an American integrated managed care consortium, based in Oakland, California, United States, founded in 1945 by industrialist Henry J. Kaiser and physician Sidney Garfield. Kaiser Permanente is made up of three distinct but interdependent groups of entities: the Kaiser Foundation Health Plan, Inc. (KFHP) and its regional operating subsidiaries; Kaiser Foundation Hospitals; and the regional Permanente Medical Groups. As of 2017, Kaiser Permanente operates in eight states (Hawaii, Washington, Oregon, California, Colorado, Maryland, Virginia, Georgia) and the District of Columbia, and is the largest managed care organization in the United States .

I just came across this paper about GnRH analogues used in children with gender dysphoria.
academic.oup.com/jcem/article/100/2/E270/2814818

This suggests that the BMD (bone mineral density) was below their pretreatment potential and either attainment of peak bone mass has been delayed or peak bone mass itself is attenuated.

Despite these limitations, our findings are relevant given that most the patients currently treated in our clinic is late pubertal at start of GnRHa treatment, as is observed in other transgender populations (21, 22). If CSH is postponed beyond the age of 16 years it should be taken into account that these subjects may be particularly prone for loss of bone mass. In addition, concerns for possible long-term deficits in bone health may be amplified in subjects who present at a more “ideal” pubertal stage, ie, Tanner stage 2–3.

In short, expect children who are on these drugs to end up with crumbling bones. The younger they are when they start on the drugs, the worse this is likely to be.

Lupron is the US trade name for leuprolide acetate (synonym leuprorelin acetate). In the UK it is marketed as Prostap which is licensed for use in children to treat precocious puberty. Triptorelin (Decapeptyl) is also licensed for precocious puberty. I don’t know which of these are used for delaying puberty in transgender children.

The SPC for triptorelin has some fairly hefty warnings about cessation at the time of normal puberty. There’s no information about what happens if treatment isn’t stopped at this time, unsurprisingly.

It’s interesting that there are no peer reviewed published papers about long term off-label use. I’ve seen one linked on here somewhere that the poster was claiming to show evidence of safety, but if you actually read it it was clear that there are many unknowns.

That’s quite shocking, Oldcrone.

expect children who are on these drugs to end up with crumbling bones. The younger they are when they start on the drugs, the worse this is likely to be

Horrifying. A friend of mine was poisoned by steroids and her bones were crumbling, how anyone can do this to a healthy child is beyond me, particularly when we are talking about doctors who should know what they are doing.

I have steroid induced osteoporosis.
I have a lot of pain and have had multiple fractures.
I wouldn't wish it on anybody.
To inflict it deliberately on a young person is immoral IMO.