XY woman gives birth?

[ItsAllGoingToBeFine]

A 46,XY mother who developed as a normal woman underwent spontaneous puberty, reached menarche, menstruated regularly, experienced two unassisted pregnancies, and gave birth

www.ncbi.nlm.nih.gov/pmc/articles/PMC2190741/

If this is correct, does this mean that chromosomes don't determine sex after all? Riley J Dennis etc are all tweeting that that is what I means.

I am instinctively dubious, but don't know own enough to make an informed judgement.

I am hoping that Bowl is around

This is an intersex condition and the patient has genetic mosaicism. Very rare condition with different genes in different cells, rather than same DNA in all cells of the bidy as per normal.

So they have XX and XY cells? Incorrect to describe as an XY woman?

Trans activists, forever appropriating intersex conditions and genetic abnormalities.

Disgusting.

In this case they have X and XY cells.

See here tps://en.m.wikipedia.org/wiki/Gonadal_dysgenesis

ie a severe genetic abnormality.

Chromosomes most definitely do determine sex, specifically the SRY gene on the Y chromosome, in humans. In some abnormal condition, the normal process of sex determination in the womb doesnt happen because the foetus has a mutation that effects the SRY gene or the hornonal cascade pricess it initiates.

"Testis-determining factor (TDF), also known as sex-determining region Y (SRY) protein, is a DNA-binding protein (also known as gene-regulatory protein/transcription factor) encoded by the SRY gene that is responsible for the initiation of male sex determination in humans. SRY is an intronless sex-determining gene on the Y chromosome in therians (placental mammals and marsupials); mutations in this gene lead to a range of disorders of sex development (DSD) with varying effects on an individual's phenotype and genotype.

I don't know why this is all such a mystery to many TRAs (lack of scientific education? didn't do A level biology?) It's very well understood. The presence of a Y chromosome causes a foetus to develop as male in human males that have XY sex chromosomes as one of their 23 pairs of chromosome in every cell. If you have no Y chromosome and 2 X chromosomes instead, you have XX in every cell and develop as a Female.

Of course there are a myriad of ways that this process can go wrong or different from the norm, like thousands of other genetic abnormalities, mutations, conditions, illnesses like cystic fibrosis, cancer, mitochondrial disease, haemophilia, intersex conditions etc etc etc

Fascinating, and exceedingly rare. They seem to have a number of different mutations as well as mosaicsm (where the organism contains a mosaic of cells with two or more genotypes.)

The X only cells seem to be 45X and so that in itself is unusual ( just from a quick scan.)

Seeing a few genes I’ve worked on in here too

No it tells you nothing about transgender (sigh, for the twenty billionth time) butvits an interesting read, especially the other genes they’re looking at ...it’s interesting to see they screened extensively to see if the individual’s parentage matched as well.

The daughter is infertile.

Read the article in more detail and the mother also had

This is an unusual case, it arose from a specific set of circumstances, and it shows the rock bottom level of understanding and empathy of the people who jumped on it as evidence to support their own claims.

Its difficult to discuss as this is an actual family, not a hypothetical case.