Define "offend"
This is what's important.
Insulting someone because of their sex/ gender identity / religion / race etc is offensive. So if/when people are just trying to score cheap points on MN then it is a bit offensive. There's so much to debate without 'well I disagree with HIM look everyone see what I did there. I'm so funny '
But having a debate saying 'actually we need to seriously discuss how/why we have biological men claiming they have menstrual cycles and periods but without blood' is needed and not offensive. Some people may not like that debate, but it is reasonable.
Saying to a religious believer they are crazy and delluded is insulting, as is saying a transperson is 'delluded'. Some may well be living in a fantasy world, some may genuinely have feelings of gender dysmorphia, there's a whole range of experiences, but attacking the person or group is unkind and unhelpful.
But critiquing the basis of a holy book, debating the terms of reference for a religion, discussing thr impact of a religion would be totally reasonable. Discussing personal gender critical views, the implications of GRA, the implications of having newspeak and basic biology redefined etc are all reasonable. Some may not like that debate, but it isn't offensive.
People really ought to (in my opinion) go high. Let the TRA go low and show themselves up.