Ok... hormone blockers... what are the downsides?

[loveyouradvice]

Medical opinion seems to present these as "hitting the pause button" and that the impact can be reversed at any time, by just stopping taking them....

I've caught glimpses on here that it is not quite that simple....

Great if someone could fill me in on the science re negative impact/risks?

Do you mean as is puberty blockers?

This is a rather accessible article right here. It's also scary as fuck!

www.statnews.com/2017/02/02/lupron-puberty-children-health-problems/

Lupron is the brand name - the generic name is GnRH analogues.

The NHS advises that adult women should only take them when all other treatments have failed and for a maximum of six months, due to the serious side effects:

www.nhs.uk/conditions/pre-menstrual-syndrome/treatment/

But if you are asking about using them on children for not conforming to gender stereotypes being trans, they are absolutely a-ok, 'fully reversible', just keep taking them, nothing to worry about here:

www.nhs.uk/conditions/gender-dysphoria/treatment/

"In the interviews with women who took Lupron to delay puberty or grow taller, most described depression and anxiety. Several recounted their struggles, or a daughter’s, with suicidal urges."

Thought this was interesting, especially considering the trans suicide stats..

Here's a twitter thread which covers pretty much the same ground:

mobile.twitter.com/tessienator/status/965539099930062848

Given on label, puberty blockers are used to delay puberty, not stop it.
When used to transition children they are given beyond the point that natural puberty would occur.
Many developmental stages such as puberty are time sensitive, you don't get a second chance.

Blocking puberty means that the gonads don't develop, the child is left sterile. They cant donate and freeze their eggs or sperm to have children later, as they never develop any.
They also never develop adult sexual desire. The effect is more aesthetically pleasing, they are more likely to 'pass', but they are eunuchs.

Its far better for people to get support to come to terms with their body, the same way most of us do at some point when we face the ageing process, or disability.

Beginning to understand why it is being referred to as our generation's thalidomide..... but in the interests of being scientific, is the dose very different for teenagers to adult women (who risk osteoporosis)?

And how can Tavistock on "I am Leo" - CBBC - state that it is totally reversible? Is it the case that perhaps it is totally reversible for say up to a year (or whatever) but if taken for longer, the effects are NOT reversible... i.e. testes development etc?

My main issue with them is that a large amount of brain development is linked to puberty www.ncbi.nlm.nih.gov/pmc/articles/PMC3410522/ but we don't know very much about it yet. If these children never go through puberty, are we running the risk that their brains don't develop correctly?

Until more studies are done, the risks can't even be described, let alone tested and I think the use of GNC children as guinea pigs is horrific abuse.

I am not expert on the effects in children, but I have been on GnRH analogues myself as an adult. They're prescribed for endometriosis, as they induce a state of false menopause, which is thought to halt the activity of endometriosis, which is linked to oestrogen levels (it's not effective, but that's another story...)

Hand on heart, these drugs ruined me. The side effects were overwhelmingly horrible.

Night sweats
Hot flushes
Panic attacks
Anxiety
Crying jags
Weight gain
Emotional chaos.

It took me months to recover after I stopped taking them. I would never give these to a child. They're not harmless, we're not sure if they are reversible, they are a HUGE deal. The children who are currently being put on them are being used as guinea pigs.

And all for aesthetic effect! There is no evidence either way if the drugs are an effective treatment for dysphoria. And it is very, very worrying that such tests that are being run show that there is a 100% progression to cross sex hormones. nothing has a 100% "success" rate. There is an iatrogenic mechanism at work here - these drugs aren't treating these children's dysphoria - they're cementing it.

And it's based on a lie - that children denied these drugs will commit suicide.

From Medscape reference.medscape.com/drug/lupron-leuprolide-342221 :

Endometriosis
3.75 mg IM monthly for up to 6 months or 11.25 mg IM every 3 months for 2 doses (6 months total)

Recommended duration of treatment is 6 months; may treat again for additional 6 months, but with concomitant administration of norethindrone

Central Precocious Puberty
Indicated when signs of sexual maturity begin to develop in girls

Wow.... going to start talking to the large number of doctors in my acquaintance.....

TL:DR version, the Lupron dose given every three months as a puberty blocker is the same or greater than the dose given to induce temporary menopause in women with endometriosis.

Despicable.

Despite the claims, no one can change sex. Its extreme cosmetic surgery, it doesn't change your biological sex. Only your appearance.

www.transgendertrend.com/puberty-blockers/

Omg so the kids dose is bigger than adults

Like Sophocles, I too have been given GnRH analogues as a treatment for endometriosis, albeit not Lupron. I also agree that these should never, ever be given to children - my side effects were also horrendous.

I was given the GnRH analogue as a nasal spray, using it twice a day for six months was horrible.

I had the depot injenction, pythagonal.

Did SFA for the endo - nothing helped but excision.

I hope you have been able to find effective treatment, it's a vile disease

Some of the clinicians 'treating' these children are now starting to partially acknowledge that puberty blockers are harmful to children - but their answer is that children should start on the cross-sex hormones earlier so that they aren't on the puberty blockers for as long:

"One of the things that happens during puberty is that the rate of calcium development increases markedly," he said. A puberty blocker slows down the rate of bone mineral acquisition, potentially lowering bone density. "This uptick is important in minimizing risks of osteoporosis later in life. So there's a theoretical harm if you put puberty on hold a long time."

The average age for puberty in girls is 10 or 11. In boys, it's generally between 10 and 12.

"As an endocrinologist, I decided years ago that if you waited until 16, which is way beyond the normal age of puberty, that would be taking an unnecessary risk,' Rosenthal continued. "We made the decision we wouldn't do that. A person needs to determine by 14 what their gender is. If they aren't sure, they have to come off the blocker."

(Taken from this article: www.washingtonpost.com/national/health-science/when-kids-come-in-saying-they-are-transgender-or-no-gender-these-doctors-try-to-help/2018/01/19/f635e5fa-dac0-11e7-a841-2066faf731ef_story.html?utm_term=.de1fa1dade38 )

As has been seen above problems 'later in life' can mean in their 20s or earlier - and, while the majority of children with gender dysphoria used to desist once they hit puberty, if you stop them from going through puberty (by putting them on puberty blockers), 100% of them go on to transition.

Thanks Sophocles I did. Sorry that you had to have excision though, that must have been horrendous.

A person needs to determine by 14 what their gender is. If they aren't sure, they have to come off the blocker.

I am 50 and have no idea what my gender is.

Tinfoil hat time but just reading what upstart wrote about creating eunuchs, is this whole movement orchestrated by some nefarious anarchist group hoping to slow the human birth rate and create a super class who’s main commodity is controlling the fertility of the rest of humanity?

takes tinfoil hat off for a scratch

No, but weird that all these kids will just never become adults eh? Permanent state of pre-puberty.

And how can Tavistock on "I am Leo" - CBBC - state that it is totally reversible?

The main disingenuous thing about this is that going on puberty blockers means, in 100% of cases, the child goes on to cross-sex hormones, the effects of which are irreversible. They just kind of enforce the trans identity.

It's often said that puberty blockers are "buying time". This is the big lie. All children who take them go on to cross-sex hormones while a large percentage of children who don't go on to desist.

Puberty blockers create persistence.

Use of blockers for 3 years (to delay puberty) was associated with a reliable drop in IQ in this study

I don't recommend watching 'I am jazz' in any way which will contribute to the viewing figures or the money being made by the kid's parents but there are many clips on YouTube that give you an idea of how crap Jazz's life is now. Depressed, weighing too much for SRS surgery due to binge eating, zero sexual function, a micro penis and not enough penile tissue to create a neo vagina so needing to have one created out of part of the bowel.
Jazz was a gender non conforming little boy who was abused and exploited by his parents before he could possibly have had any concept of the effects of what they were doing to him. Tragic.

And can we just have a bit of a think about 'pausing' puberty for a moment please? Are we saying that we keep a child in a state of suspended animation until they are legally old enough to decide if they want to mutilate their bodies or not? But they're still emotionally and physically children at this point presumably if their puberty has been paused. So how can they make those decisions?

"Jazz was a gender non conforming little boy who was abused and exploited by his parents before he could possibly have had any concept of the effects of what they were doing to him. Tragic."

It is terribly tragic. I don't know how anyone with any sense or decency can know his story and not realise the harm being done by transactivism.