As regards the Nature article, a quick skim is interesting. Particularly where they say:
"In the other tracts measured, the present study revealed, like in several previous studies, sex-atypical FA values in transgender individuals. However, and importantly, these values became sex-typical after accounting for sexual orientation."
Which was what others were saying -- some previously reported effects were actually sexual orientation rather than gender identity related. Or saying lots of researchers didn't have proper control groups..............
Certainly doesn't say TrW have ladybrains (I admit I found their terminology of TrW, HeM, HoM etc etc rather confusing!).
I was wondering whether or not they controlled for cross-sex hormone therapy? (Ah, I see they say "Exclusion criteria consisted of previous or current hormonal treatment", but you have to be aware of the availability of hormones on the black-market, so not officially prescribed hormones does not mean they have never had hormones and might just lie.)
Also interesting that the differences they did find, they focus on:
"Importantly, the present data also provide a neuroanatomical underpinning for a GD/transgender-specific aspect - the body dysphoria and great distress due to incongruence between physical sex and experienced gender."
So, they seem to think the difference they found isn't ladybrain, but instead a propensity to feel some disconnect with your body (hence dysphoria). Which, according to TRAs, isn't required to be trans.
I would not be at all surprised if there were some correlate in the brain, that explains a propensity to develop the disconnect and distress that is gender dysphoria. For those who suffer from it, we owe them the best research as to how their distress can be alleviated or treated. But this is not where current TRAs are, which is dysphoria not necessary, and hormones/surgery on demand is the thing. Totally different hymnsheet -- one group supports the ladybrain, the other doesn't.
I'd be interested to see if the differences they see are possibly related to any differences as regards those with other bodily dysmorphias? And frankly, the groups they are talking about here are the classic dysmorphic transsexuals who most people think self-id is talking about, not the actual non-dysmorphic, I don't want surgery I just have a ladybrain lot who the TRAs are actually advocating for.
P.S. I see they also excluded anyone with a diagnosis on the autism spectrum, so they seem to have done a reasonable job.