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Women's health

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Desogestrel side effects, perimenopause or both?

4 replies

Pinkmagic1 · 05/05/2026 10:12

I am 46, to be 47 very shortly and have been taking Desogestrel for a couple of years since having the Mirena coil removed due to issues. Since taking it, I have had anxiety, severe overthinking, brain fog and awful insomnia. The last few months these symptoms have become much worse to the point I have been lucky to get 3 hours sleep a night and have been bursting into tears for no reason and sometimes to the point I am shaking with anxiety.

I went through some huge life changes and upheavals around 3 years ago and even then I didn't feel like this. I have always been a resiliant person. I immediately thought perimenopause given my age and I am waiting for some blood results from my GP. However I decided to stop taking the pill a couple of weeks ago as wanted to see if this could be effecting things and already I am sleeping better and the anxiety has subsided quite significantly. Coincidence, I'm not sure?

I would be very interested to hear other womens experiences.

OP posts:
Pinkmagic1 · 05/05/2026 11:37

Anyone?

OP posts:
HeBeaverandSheBeaver · 05/05/2026 11:40

I do t know if it’s the same progesterone but my dd had terrible anxiety and panic on the merina coil and Microgynon wasn’t great either. I had terrible rage on HRT We are clearly both very sensitive to artificial progesterone

Pinkmagic1 · 05/05/2026 12:16

Thank you @HeBeaverandSheBeaver I am becoming more and more convinced that the pill has been a huge contributing factor in the way I've been feeling. It's making me very reluctant to try HRT which is something the GP has suggested.

OP posts:
HeBeaverandSheBeaver · 05/05/2026 19:39

It’s a hard one. I always say to friends it may be great for them as every women is different. The only way to know is to try for a while. I’d give it at least a few months. Good luck

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