Mounjaro A&E moving to 5mg

[Hopsicle]

I wonder if anyone else has had this experience. 2 weeks ago SheMed put my dose up to 5mg after 4 successful weeks on 2.5mg with very few very mild side effects. 3 days after the 5mg dose I was ill enough - with excruciating abdominal pain, nausea, sickness, sweats, and actual vomiting - to be sent to A&E following a call to 911. It was frightening too as they thought it could have been a heart attack.

Anyway in the end they decided it was Mounjaro side effects, put me on an anti-emetic drip then sent be home 8 hours after I had arrived.

After that I spoke to a SheMed pharmacist who suggested I drop back down to 2.5mg for another month, and I was happy with that.

But this week, I had exactly the same horrendous side effects from the 2.5 as I'd had from the 5mg dose, and now I don't know what to do. SheMed obvs don't care about wasting the 2 almost full pens I've got in the fridge but I do and just want to declare Mounjaro a fail for me and switch me to Wegovy. But I don't understand why or how 2.5 worked so well for me before but then not this time. I believe it must be able to work again, so I'm tempted to try the 2.5mg dose again this week.

Has this happened to anyone else?

You are probably very sensitive to it and due to the half-life, you still have enough of the previous doses in your system that you still got ill when trying 2.5mg again.

I personally would wait at least a week or two to let your levels reduce before trying again with 2.5mg (or even less by counting clicks).

i would take a break for a few weeks and then start again on 2.5mg.

Did you have any choice about moving up to 5mg? (You say Shemed put the dose up). I never understood the logic of increasing the dose when the current dose is working.

Did you change your diet?

The only reaction I've had was after eating sandwiches at a conference - next day was a disaster. I've not been eating any processed carbs before then.

My reaction was no where near as bad as yours. But the people who have severe reactions do often seem to be eating processed carbs, fried food etc.

Hope you can sort it out. It does sound miserable & you are not supposed to be miserable.

Hi op you will still had some 5mg in your systems so that's why the 2.5 will still be impacting you. Take 2.5 mg again when your supposed to and keeping doing that. When you feel you need to move up take 3.75mg of your 5mg pen which counts as 45 clicks and then you won't waste the pens either

Thanks to everyone who replied, this is very helpful. I am doing ZOE so eating very little UPF so I don't think it can be that.
The half-life theory makes sense though. I'm thinking I'll take 2.5 again tomorrow and give it another try. And yes if that works, I'll just count clicks and stay on 2.5 for as long as it works, then only raise it very gradually.
Thanks again!

To be honest I would recommend you look at changing pharmacies. If you were admitted into A&E, I’d be expecting your pharmacy to proactively investigate why this happened and whether other medication is suitable. It seems like you have a lack of clarity & they really should be the ones to give you that. Maybe switch to another pharmacy and see if you find one that is more patient-focused.

How are you now @Hopsicle ? Did you stick with MJ?

Hi, thanks for asking. The answer is that following a short battle with SheMed, I went back to 2.5ml for 4 weeks, then increased the dose only very slightly to 3.1 mg (by doing 37 clicks on a 5mg pen) 2 weeks ago. I will now stick at this dose until I start getting hungry again. Clearly I’m very sensitive to the drug.

Well done. It sounds an awful experience (I'm terrified of doing more damage to myself than I already have!) and yes you sound like a super responder or whatever they're called.

Have your symptoms been okay since? Im glad it's working for you though after all that x.