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Women's health

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GnRH Analogues for Endometriosis and PMS

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Winglessvulture · 28/08/2024 07:16

I'm hoping that some people might be able to share their experience of taking GnRH analogues for Endometriosis and/or PMS.

I was diagnosed with endo in 2019 following a laparoscopy where the lesions were removed. Within a year the pains started to return, but I fell pregnant and found the symptoms were broadly fine during this time and for about 3 months after the birth. Since then the symptoms have been returning: pain from ovulation through to period and for the first few days of the period (pelvic, lower back, upper legs) even worse fatigue than normal (I was diagnosed with CFS when the fatigue that I experience daily was not resolved following the removal of the endo), mood swings (particularly feeling depressed from ovulation to period, worst in the final week before period).

I saw a specialist yesterday who discussed a variety of options, but felt it might be beneficial for me to try GnRH analogues. I was offered these previously before my surgery as a way to suppress symptoms while I waited, but I decided against it as I was nervous about the side effects and any impact it could potentially have on my fertility moving forward.

I am unlikely to have any more children due to my fatigue, and therefore I am considering them this time. However I am curious to know what symptoms they have resolved for people, Vs what side effects they got. The symptoms that bother me the most are the fatigue, the mood swings and the bloating/water retention. Has anyone found they help with these? I am particularly concerned that it could make all, or any, of those symptoms worse. I have got so used to living with the pain that whilst it is there I tend to just carry on with things, but the specialist felt that perhaps by getting rid of the pain that could potentially improve my fatigue (and my mood).

I have previously used the combined pill, which suppressed my symptoms for years as a teen/in my 20s and had some impact when I restarted after having my child, but had to stop taking as I was getting cervical errosions. I now have a Mirena coil which has also helped - the pain is less and the moods are also reduced, but all the symptoms still remain.

Thank you for your help!

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