So far, after terrific amounts of honing:
Blindness by Jose Saramago - for stripping away the veil and laying bare the truly terrifying black heart of humanity.
Blood Meridien by Cormac McCarthy for the blood. I spit on your nimby pimby The Road
Creation (and everything else he wrote ) by Gore Vidal for the sheer genius and damn good story encasing Buddha, Confuscius and er I 've forgotten the others
The Vivisector by Patrick White for the ASTONISHING writing and capturing of the essence of artistry
I would have Such a Long Journey but we've had that a lot, so I'll have The Cider House Rules (which kicks stupid Owen Meany's arse), for the wisdom and humanity.