Cloud Atlas (what prompted me to start this thread) - lesser than the sum of its part. It's all very clever and a very impressive exercise in writing and authorial(sp?) skill, but none of that makes for an enjoyable read. Too stop start, didn't like some of the stories, didn't feel the stories connected enough to make it feel like they deserved to be all wrapped up together. Emporer's New Clothes.
The Great Gatsby - too deliberate, too studied. I felt like Fitzgerald had written and rewritten and rewritten again every single word on the page, and so the story lost any sense of urgency or liveliness. It left me feeling very cold, which did annoy me as the bones of the story were really interesting.
Paulo Coehlo's The Alchemist and The Life of Pi - couldn't read more than 2 pages of either of them, just hated them on sight.
Anything by Dickens - I just can't get into him
. Ditto anything by DH Lawrence.