grendel - your post has made me go and look out my copy again as I think it may be time for a re-read
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I read it when it came out in paperback and was amazed to see that that was about 10 years ago!
It was such a powerful book and she describes the intensity of Jacob's passions so vividly that it has stayed with me ever since.
Bearing in mind that these days most books I read I seem to forget the plots almost instantly, yet I can remember almost everything about AMLS.
Someone picked it on A Good Read a few years ago, and they all loved it too.