Mounjaro - How safe is it?

[Biosblbay]

Since my 2 children I have gained 3 stone, in 4 years I have gone from a size 10/12 to now a 14 pushing a 16 potentially. I don’t have time to go gym like I used to, all I do is walk on a walking pad while I work from home which isn’t helping budge the weight at all and I am far too tired to go gym in the evenings having working a full time job and have a just turned 1 year old and an almost 4 year old. My baby still doesn’t sleep well so I am just so tired (this also probably doesn’t help with weight either!).

I really want to do mounjaro, I know so many people that do it with title side effects such as bowl issues or nausea which I can deal with. What I want to know, has anyone else ever experienced much worse than this or it even cause any serious complications. I have read it can be fatal which scares the hell out of me, but how common is this?

Just needs some advice really. Thank you x

Pancreatitis is a known side effect, which CAN be fatal. But as others have said, it is rare and some people will be more at risk, so may be advised not to take it. The most important things are 1) to get it prescribed from a legitimate source and 2) not lie in order to get it.

No it’s not. Pancreatits is due to many factors, taking mounjaro isn’t one.

https://ascopubs.org/doi/10.1200/JCO.2026.44.2_suppl.712

https://journals.lww.com/ajg/fulltext/2024/10001/s5_glp_1_receptor_agonists_and_pancreatic_cancer.6.aspx

https://www.dailymail.com/health/article-15879295/pancreatic-cancer-remarkable-link-mounjaro-fat-jabs.html

I didn't say pancreatic cancer. Pancreatitis is listed in the UK licence data sheet as an "uncommon" adverse reaction. This is a fact.

Go for it! x

Pancreatitis isn’t pancreatic cancer.

I’m assuming you didn’t even bother reading rhe articles sigh.

and @hansenhen , I think everyone knows that.

Oh, I assumed you didn’t as you linked to articles about pancreatic cancer whilst talking about pancreatitis. My mistake.

It also mentions pancreatitis.

but if you can’t be arsed googling here is some specifically for pancreatitis.

it actually reads like people are gutted there is no increased risk,

The 14,600+ Participant Meta-Analysis: Published in Obesity Science and Practice, this systematic review and meta-analysis analyzed 17 randomized controlled trials involving 14,645 patients. It found identical risks of pancreatitis across all Mounjaro doses (5 mg, 10 mg, and 15 mg) compared to placebos, insulin, and standard GLP-1 receptor agonists. You can read the study details on PubMed Central (PMC11667760). 1, 2]

The 40,000+ Patient Placebo-Controlled Study: A large pooled meta-analysis encompassing 31 placebo-controlled trials of semaglutide and tirzepatide examined a total of 40,274 patients. It confirmed that neither drug class demonstrated an increased risk of acute pancreatitis compared to a placebo. The full preprint is available on medRxiv (2026.03.19.26348844v1). 1]

Early Phase 3 Safety Foundations: An earlier meta-analysis evaluated the safety profile of tirzepatide across 9 foundational clinical trials with nearly 10,000 participants. This study also established no statistically significant association with pancreatitis, though it noted separate trends regarding gallbladder and biliary tract changes. It can be found via PubMed (37908750). 1]

Did you read the bit where I said ‘my mistake’?

I thought you were being sarcastic, as it’s the go to for many on here sigh.

anyway, yes there is no increased risk of pancreatitis on the drugs, it seems some sort of urban myth, I keep seeing people posting it, and many arguing blind and appearing almost gutted when they realise it’s not true.

not only as said is there no increase in the risk of pancreatitis , we also know pancreatitis can lead to pancreatic cancer, which the drugs reduce the risk of significantly , hence my links on both.

obese people are at risk of pancreatitis in the base case due to blood fats. And losing weight reduces the risk, so as long as no one is silly about losing weight, then your risks reduce.

im assuming the op isn’t looking at the drugs as a first resort to lose weight, but the last, like everyone else. As such pancreatitis is really not something to avoid the drugs for, if anything it would encourage anyone to use them, as yoire no more likely to get it. Yoire at high risk being obese, and it can lead to pancreatic cancer if you do get it. Which rhe drugs protect against for many.

so overall if the op gets pancrearits, the convo, as said, with her kids will not be she got it due to wli, it will be as she is obese or lost weight rapidly and fucked her gall bladder. As obese people stand a 3 to 4 times more likely chance to get it than healthy weight people. People on mounjaro stand a zero percent higher risk than people not on it,

@mumofoneisonozempic already got it in the fridge. Was ready to start Tuesday but they hadn’t sent the needles so I am going to start after the weekend. Very very nervous to take it though I must say. I will most likely take it before I go to bed. @davidleothe side effects you have listed I deal with most days already anyway so hopefully it isn’t a massive shock to the system for me. I just hope this is all I get and nothing more serious! @AgnesMcDoo I have a walking pad so my goal is 5 miles of walking every day and I want to start going for a job twice a week in the evenings, I hope that’s enough! My diet is pretty poor in terms of skipping meals or eating a crossaint for lunch due to working and having 2 young children but I need to change that! I am hoping being on mounjaro will actually give me the kick up the ass I need to eat better as I want the best results!

Thank you everyone who has posted that has highly recommended it and only have mild if not no side effects! I have been watching videos on social media that so many people have said the only they regret they have is not taking it sooner. Wish me luck!! X

Good luck op, if you don’t like it, you just stop, there is no commitment there.

ive been on over 2 years, on a maintenance dose, bmi 2o size 8 from an 18 and bmi 32, I feel great and blood tests are all optimal.

80 percent of people have no side effects. You need to get your eating under control though, you can’t skip meals, starve yourself etc as you will be unwell, so a good clean healthy diet, in a calorie deficit and regular meals, and you should be fine.

This. Glad you decided to go for it! Good luck. I lost 6.5 stone in just over a year and it's amazing.

Also, find the starting thread for your month - might not exist yet as it'll be August (you could start one!). Then you can get chat and support and compare notes with people at a similar point to you.

There are risks, but there also are to carrying excess weight. Its why there are BMI parameters- because the risk balance is weighted to MJ.