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Weight loss chat

A space to talk openly about weight loss journeys and challenges. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any diet.

Just taken my first jab of mounjaro…what to expect?

16 replies

JudesBiggestFan · 10/05/2026 12:47

So after feeling very anxious, I’ve taken my first shot of Mounjaro, 2.5mg…it was super easy in the end! But now sitting here, waiting to feel…something? I’m down from a size 18-16, having lost 1.5 stone through concerted efforts. But after a lifetime of trying, I know I always plateau around this point, struggling to consistently cut calories enough to lose more. I just want to get to a size 12 and feel that I can wear whatever I want and just not even have my weight be an issue in my mind! I swim and walk and live a full busy life, but other than in my teens when I fleetingly starved myself down to a size 10, I’ve variously been chubby or just plain fat. Despite a lifetime of diet and gym memberships! I also have ulcerative colitis, which is now stable, but long periods on steroids have also not helped. It’s been such a battle and at 46, I had almost given up Dare I hope that this will finally be the thing that works?!

OP posts:
RS1987 · 10/05/2026 12:54

in my experience, you’ll wake up tomorrow feeling like a magic spell has been cast over you as you don’t care about food. Then you’ll get diaorreah and eggy burps

Watcher2026 · 10/05/2026 12:55

Not something I would try and I wonder how much is still loss down to life changes or jab as all the info clearly says stick to a diet etc also...hope it works keep updated

JudesBiggestFan · 10/05/2026 12:57

RS1987 · 10/05/2026 12:54

in my experience, you’ll wake up tomorrow feeling like a magic spell has been cast over you as you don’t care about food. Then you’ll get diaorreah and eggy burps

Ha ha , i’ll look forward to that! Has worked for you weight loss wise?

OP posts:
JudesBiggestFan · 10/05/2026 12:58

Watcher2026 · 10/05/2026 12:55

Not something I would try and I wonder how much is still loss down to life changes or jab as all the info clearly says stick to a diet etc also...hope it works keep updated

I have been very unsure. But so many people at work have lost loads on it. I’m just working on the basis that if it doesn’t work/has bad side effects, I can just stop. We will see!

OP posts:
KnewYearKnewMe · 10/05/2026 13:03

Watcher2026 · 10/05/2026 12:55

Not something I would try and I wonder how much is still loss down to life changes or jab as all the info clearly says stick to a diet etc also...hope it works keep updated

not able to answer OPs question then, are you?!

OP
I’m 18 months on. In the early stages, I’d feel tired after my jab and a bit spacey.

i immediately had a much reduced appetite and like another poster said, a magical absence of any food noise.

as the week wore on, my appetite increased a little until the next jab.

for me (and many) it’s been a wonder drug 🙏🏻

Bulbsbulbsbulbs · 10/05/2026 13:06

I had no side effects at all. I lost 3 and a half stone. It's great.

I was just not interested in food much beyond at meal times when I could usually manage half a portion as I'd feel very full, like I'd just had Christmas Dinner. I cut out carbs almost completely. Sadly I now crave bread again!

FormerFatty · 10/05/2026 13:12

If you’re like I was, by tomorrow you will have no interest in food and will be full after 2 or 3 mouthfuls.

I felt completely fantastic throughout, even as I titrated up to 15mg. No nausea, gut issues - absolutely nothing. Just an incredibly easy loss of over 50 pounds, which has stayed off for over a year.

Good luck!

waitingForSpring01 · 10/05/2026 13:24

I am 9 months in and I am very close to target weight. For me it has been like magic. No side effects and never had to go higher than 5 mg. After the first injection, I had a very mild upset stomach, and when the weight loss increased, I felt a bit tired, but other than that no negative effects at all. I am more energetic, no pain in joints, more confident and generally much happier. Ah and it also helped a lot with wine cravings - that was an unexpected and very welcome effect. Good luck!

KimTheresPeopleThatAreDying · 10/05/2026 13:28

waitingForSpring01 · 10/05/2026 13:24

I am 9 months in and I am very close to target weight. For me it has been like magic. No side effects and never had to go higher than 5 mg. After the first injection, I had a very mild upset stomach, and when the weight loss increased, I felt a bit tired, but other than that no negative effects at all. I am more energetic, no pain in joints, more confident and generally much happier. Ah and it also helped a lot with wine cravings - that was an unexpected and very welcome effect. Good luck!

Same here. I have nothing but praise for it. Really has changed my life.

34feeling54 · 10/05/2026 13:32

RS1987 · 10/05/2026 12:54

in my experience, you’ll wake up tomorrow feeling like a magic spell has been cast over you as you don’t care about food. Then you’ll get diaorreah and eggy burps

I woke up the next morning feeling exactly like the magic spell had been cast. But NEVER experienced diorreah or burps!

Burntt · 10/05/2026 13:35

I woke up next day extremely nauseous. That lasted 48 hours. Horrible eggy burps. That was it.

I found I had a banging headache because I wasn’t feeling thirsty along with not feeling hungry so remember to drink water!

JudesBiggestFan · 10/05/2026 13:36

This is all so encouraging. Thank you! I just can’t believe after a lifetime that there might be a cure for something that bedevils so many of us. I will report back!

OP posts:
AgnesMcDoo · 10/05/2026 13:41

Some people get side affects and some don’t.

I lost all food noise felt satisfied and filled by small portions of food for the first time in my life.

eating healthy and controlling calories became easy and as I lost weight exercise became easier.

some times I got sulphur burps and sometimes if I ate too many carbs I got diarrhoea.

if I didn’t eat enough I felt very tired.

I’ve I got used to understanding these I was able to control all with diet.

I stopped and reversed hair loss by taking collagen and vitamins.

I’ve lost 5 stone and am down to size 14-16. Which looks good doesn’t height.

AgnesMcDoo · 10/05/2026 13:42

Watcher2026 · 10/05/2026 12:55

Not something I would try and I wonder how much is still loss down to life changes or jab as all the info clearly says stick to a diet etc also...hope it works keep updated

And what experience of taking WLI do you have to share with OP

all of it is down to diet. WLI don’t melt fat 🤣

Cyberjammies · 10/05/2026 13:42

I felt a bit spaced out for a couple of days then tired and had a bit of gas, but generally fine! My achey legs vanished overnight though which I did not expect so that was a bonus!!

MissBridgetJones · 10/05/2026 13:46

What @RS1987 said. Although I never got the eggy burps. It really is some kind of sorcery! Be prepared for an upset tummy. I felt freezing cold for about two weeks. I had 3 stone to lose, it took 5 months. On a maintenance dose now. Best of luck x

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