What happens when the 1.0 dose wears off? (Ozempic)

[greylad]

I could feel the effects of 0.25 and 0.5 wearing off in the second half of the months, and sure enough I put weight back on in weeks 4 of 4 on both doses.

I went up to 0.75 two weeks ago and sure enough can now feel the effect wearing away and my weight loss has stalled.

So now I’m worried that the effects of 1.0 will also wear off after four weeks. Has this happened to anyone else?

Yep me. It lasted about 4 weeks. I swapped to saxanda and I'm currently on 2.4 (second to highest dose) but I'm sure when I move up to 3.0 I will only have a few weeks til it wears off.

Crumbs, I was hoping it wouldn’t work like that!

Out of interest what is the 'effect' that you feel wearing off ?

I’ve been on 1.0 for around three months. Some weeks the appetite suppression seems to be more effective (strange!) and over the last fortnight it has been working very well. I’m going with it for now as am still losing and I can’t go up a dose until Wegovy is available. If I really struggle I might consider switching to another medication such as Saxenda.

Appetite suppressant. A feeling of not being hungry, and/or a feeling of being full after just a small portion of food. It’s amazing really and makes me think that this must be how ‘normal’ people feel. Not always thinking about food and planning my next meal. Knowing when to stop. Not over-eating.

So far, these effects have worn off after three weeks on each dose.

The thing is Ozempic isn’t all about appetite suppression. I think Saxenda may be more so but I’m not sure. Ozempic is about blood sugar control and a side effect is appetite suppression. And that is partly why Wegovy is the drug which is sold for treatment of obesity. Yes it’s the same drug but a lot of people need the higher dose for weight loss.

when you start Ozempic you are on a very low dose which is purely to get your system used to the medication. It’s not a therapeutic dose for weight loss although some people do lose some weight. Some people have no side effects on that dose at all - no weight loss or appetite suppression which is because it’s not a dose for weight loss. 0.5 is very effective for some people for a long time. But not everyone. Same for 1mg.

I have just gone up to 1.5mg but it’s too early to say if it’s having much more of an effect than 1mg was. I think it is.

The Zoe podcast here covers a bit about how some people take longer to respond.

Does anyone know of when Wegovy is released, can we swap over from ozempic or do we have to start again from lowest dose of wevogy even though it’s the same main ingredient?

I don’t think anyone really knows yet @OzHopes. I think from now I’m going to try to stick to one supplier who will have my history a bit as it were.

Thanks Peridot1, I’m just anxious just now about running out of ozempic and thinking about other options :)

Ozempic is a drug for life, because when you stop, even if you follow the diet recommendations, are cared for by dieticians, know and apply the ins and outs of lifestyle, you put the weight back on as the trials have shown.
Many starts Ozempic without knowing this, but all the trials participants regained two third on average of the weight lost.

And for those for which it doesn't seem working as well, you are probably not eating enough carbs. Ozempic raises insulin but to do so, it needs carbs.

@Peridot1 have you told your supplier you are using 1.5 now? How long did you feel 1.0 worked for you?

After 5 months on 1mg I’m stepping up to 1.5 because the appetite suppression isn’t as strong.

@greylad - no I haven’t told my supplier. Mainly because I’ve used a few different ones recently. Although QuickMeds did approve me for their 1.5 dosages. But couldn’t actually supply it!

Im not sure really when I started on 1mg. I know I did well on 0.5 for a while and then when I went up to 1mg I didn’t feel it was as effective. So like a lot of others at the time I was advised to split the dose and take 0.5 twice a week. Which worked well. Although it’s not recommended.

so I’ve fiddled around a bit with dosages. But switched to 1mg a week consistently five weeks ago. It’s definitely not working as well as I’d hoped hence increasing to 1.5.

How do you get ozempic in the uk? I’m overweight - I’ve just no idea how to get it. And if you have axa medical insurance does that pay for it?

@CatsTheWayToDoIt no I doubt Axa would pay for it as most private health insurance doesn’t cover weight loss.

It is a drug for diabetics which has a side effect of weight loss. If you are not obese you probably would not need it.

you could also look at Saxenda which is similar and is available from Lloyds pharmacies and Superdrug