I wondered if anyone has experienced this. I have been on meds now for a good year - Rmipril 10mg (blood pressure), Amlodipine 5mg (Blood pressure), Fluoxetine 60mg (antidepressants) and lastly Elleste 2mg (hrt). My weight has gone up 3 stone, I get fluid retention too. I have tried so hard to watch what I eat, almost virtually given up on alcohol, tried moderate exercise (cannot seem to do much without getting really exhausted) and I am staying the same weight!!! I am constantly tired, no get up and go whatsoever and feeling so bloody miserable it is unbelievable. I go on holiday in 8 weeks time and I really wanted to go from my current size 18 at least back to a 14 and I cannot seem to do it. Has anyone found a way of losing weight whilst on meds?