I'm working in Thailand and have friends who work or have worked in both China and the ME. Obviously they are very varied locations but in general, most teachers who work abroad love it! Many go for an adventure for a few years and never go back to their home country.
In any of the locations mentioned you could live on one salary if you were on a very good package (so a top school) but it wouldn't necessarily be easy... depends on your lifestyle and if you have kids.
Most schools will offer a huge subsidy or entirely free places for your kids but this is often capped at 2. School fees can be crazy so this is a factor if you have 3+!! Some will not include such generous subsidies, you have to be sure before you can do any maths on your living expenses etc.
In Thailand we have great weather if you like hot and humid, but air quality is rough one and off for a few months of the year. It's worse in most Chinese cities, though.
We have a LOT of international schools in Thailand so the chances of finding a suitable job are high. Lots of people start their international teaching careers in Thailand and can then move on once they've got some experience.
Bangkok is a busy, dirty city with terrible traffic but great public transport. It isn't as cheap as people think in terms of accommodation etc but food is great and cheap, unless you eat at high end places and shop in expat supermarkets...!
Medical care is fantastic but you need insurance (should be provided by the school, if not you don't want to work there).
Access to islands and beaches is a huge bonus for many people, but also access to so many great locations across Asia. I have small children and a husband with very limited holiday so I'm not that adventurous, but my teacher friends go away every holiday to Thai islands, Cambodia, Vietnam, Japan, Korea, HK etc. There's a lot of travelling to be done here if that's what you're into!
It can be very difficult for a spouse to find work, depends on their industry. Some industries are strictly prohibited for foreigners (including most trades and skilled work) and all industries/companies are strictly limited as to how many foreigners they can hire. You pretty much HAVE to have a degree to get a work visa. Obviously a lot of people are working unofficially and not declaring it, or working online.
Nanny/helper culture is the norm here, and if you have kids that is a total game changer. If you don't, you can still have a part time cleaner who does your ironing and maybe your shopping or cooking. Most people do. I'm a little ashamed to say that I now cannot imagine life without a helper! Mine is a nanny who happens to do a bit of cleaning if she has time rather than one of those magical, all-singing, all-dancing helpers that do apparently exist, but she is devoted to my children and it's a joy to watch them together. She lives with us which also means both my husband and I can work without having to constantly consider who does which school run and who can be back for tea. I'm expecting a third child now and cannot imagine how both my husband and I would have careers if we lived in the UK. We couldn't afford to both work when I had my second, which is ridiculous given we are both professionals on sensible salaries.
We have no plans to go back to the UK... life for us right now is great. I have some frustrations in my job but they are different from in the UK. You do have to be quite resilient and open-minded to get along in a school abroad, more so in some locations (e.g. China would be more of an adjustment than ME or Thailand, I would say).
My life outside work is simply not comparable with how it was in the UK... here I can afford to go out with friends, I live in a great house with amazing neighbours and my kids play out unsupervised (and they are both under 5!) because it's a secure compound and the older kids hang out with the younger ones, we don't spend much on days out etc although there are all the usual cinema, ice skating, kids play places available, because we can go swimming every day and play outside all year round. A walk to the market up the road - and all the things they see there - is way more fun than a walk to the corner shop in the UK!
I'm the sort of person who always has itchy feet so will always be looking for the next move, but my husband would happily stay here, in our current jobs and current house, indefinitely!
I've waffled on a lot but if you have any specific questions, please do ask!