My cat hates having her monthly flea drops, she's a rescue semi-feral and I'm sure she can read my mind when it's that time of the month, so she'll keep running away until she finally settles somewhere and I can apply it by stealth, and then she is scared of me for a couple of days 
She has no irritation or anything at the site, and the one month so far (out of 17!) that I got it on without her realising there was no drama at all. It's like it's the knowing it's going to be done and then that she's had it done that is traumatic (she's a calico with those pesky tortie genes so who knows what's going on?!).
So, today she had her booster and we're switching to Bravecto so we only need to do this every 3 months.
But, the box says you must wear gloves, which is going to be tricky as I'd need to wear them for half a day while I wait for an opportune moment and she will then associate gloves with the dreaded drops and it will all be just as stressful for her. And she'll probably rip the gloves anyway.
TL;DR: if you use Bravecto do you wear gloves?