Ive tried different methods over time but this is the best that works for me over the past few years and with this cat i have.
If its worming powder, i mix it with a little water in a syringe and have it ready out of sight, giving it a good shake to mix it, if she sees it the game is up for that day, i need not go any further as she knows my plan
Flea tablet - salted butter - a tablespoon on side of a saucer for me to work from
Syringes - just water x 3 to help wash down the nasty tastes
Treats - on the saucer to help make things better
a towel if needed just in case (to burrorito),
I lie down flat on the bed and get cat up for some treats (meaty stick), the towel is lying loose acroos my chest so it is a layer but enough that i could wray it up if needed at any second, i cuddle her into my armpit firmly (usually my left) so i have a good grip,
I gently open her jaw with a finger from my right hand and squirt towards back of mouth, i am using my left hand to keep her in place and leaning forward on her belly for her medication,
Wormer tastes nasty, she gets a treat and i wipe her with a tissue any that has gone around her mouth while im talking all the time how good she is and how proud i am of her,
Then comes the blob of butter, it goes in between teeth at the side followed by tablet which she immediately tries to spit, i cover her eyes with my left hand and hold her mouth shut with my thumb and first finger, i stroke her throat with right hand, i blow on her nose several times as well and i repeat these 2 actions until i know she has swallowed and isnt going to spit out,
Then staight in other side of mouth between teeth when she is lying on her belly again but secured by my right hand this time is a 5ml syringe to flush and make sure the tablet hasnt got stuck in her throat and isnt burning her,
After all this violation, treats are produced and she is usually put outside on those days due to the fleas if they are any jumping off and effects of the wormer and then taken back in, later in the day for a hot bath, good teeth brush and a manicure oh and treats...... lots of treats.
Before someone points out cats clean themselves, the bath helps after she has been scratching all day, gets extra food that night as usually starving as prob having squits too and after her bath, i put her into her crate for about 1-2 hours to relax and wind down and place the crate beside the radiator with heating on full blast so she gets the full benefit