You will lose spontaneity - no staying out for a drink after work, no random trips here and there, as you have to get back to the dog.
DH lost out on a chance for a great promotion because it meant too many nights away, and we couldn't juggle that with the needs of the dog.
It has cost us tens of thousands of pounds (not even counting the lost promotion) - vet/trainer/behaviourist/grooming, pet sitter the one weekend we tried to go away but the dog played up and we had to try kennels, another fail, dog was miserable, so now no more trips as a family - I regret this so so much. Suppose we've saved money not going abroad! Yeah great. DCs have been on a couple of school trips abroad, and one with my parents. It is not the same.
And I am SICK of the dog poo in my garden (DH toilets her there, rather than on the street as we consider that unfair on pedestrians who didn't choose this life, even picking it up, there is trace, isn't there.). He does pick it up, obviously, but I hate seeing her take that shitting position, and spoiling my garden.
And occasionally she has vomitted in the house, and boy, does that spoil the day. NOTHING like when DC would throw up, AT ALL.