I think the answer to this is very breed dependent.
In my main breed, which is very amenable, I love both and all are generally easy to live with, being generally sociable with other dogs and people. The girls are cleverer but can be a bit hormonal, so the males are probably a bit more easy-going. As with most (all?) breeds, our males are larger and male coats are heavier. This can make them more impressive in appearance, but there is obviously a coat care consideration, and they don't seem to do that proper once a year clear out that bitches do. (Neutering can make the coats much harder to deal with in both.)
In some breeds, males are far more challenging, significantly stronger, less sociable with other dogs both in the home and outdoors. As a poster up above said, look at rescue centres and note the balance of males to females that have found themselves there. It is no coincidence.
Primarily though, you need to investigate this as just one of the elements of the breed(s) you are considering.
(Also note that many not-so-good breeders will convince you that males are easier, purely because bitches are easier to sell!)