Hi, I used to work in labs so it involved a lot of hand cleaning. I tried tons of creams the only one which left my hand nice and soft is Neutrogena, all kind is good but I haven't try their antiaging one yet (I am 40 and still have better hands than some 25 I worked with). Usually twice a day is enough but if you feel dry you can use it more. Also it is cheap enough and you can find it anywhere.
Also in case of very dry/damaged hands, as a punctual quick fix, use Elisabeth Arden 8 hours cream skin protectant (very expensive but a small tube last about one or 2 year). You can use it for lips hands, feet, small burns, sore nipple..... massage your hands and nails before going to bed with a small dab, and after a few days miracles happen. Don't use their hand cream though, expensive and rubbish.
hope that helps