I have a lot of saved searches and find the algorithm works well - it quickly starts recommending stuff you'll actually like.
Good advice so far on here but I'd add - don't be afraid to ask for a label photo to check sizing, washing instructions and fabric.
I generally filter to BNWT, BNWT and very good condition. I also filter sizes to M/10, L/12, and XL/14, as I'm usually 12-14 and that usually covers it. Then I carefully check the sizing on each listing (don't take it for granted!).
It's great, as a pp said, for finding more of something you already have - I do a lot of that as if I love something, I like to have two of it!
My preferred brands on Vinted are usually Toast, Hush, Seasalt, Plumo, Finisterre, Rapanui, sometimes Boden. These might not be brands I like all the time, but at least I generally know they'll be good quality enough to last second-hand.
If you're selling, you can set yourself to holiday mode if you're away and can't post. Also, check your postage settings - more than once I've had to manually disable a print-at-hone label postage setting that Vinted has imposed on me - I have no bloody printer so digital label is my only option!