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Anti androgen medication peri menopause

23 replies

HisHobbyIsSex · 18/05/2023 16:56

I'm interested in being prescribed androgen blockers. I'm perimenopausal and hair on face and body is getting ridiculous. It's always been bad, but I was on dinette in my youth, and somehow managed.
I'm on hrt already, but who should I go to for prescription of anti androgen- a dermatologist? Gynaecologist? GP pointless and I will do it privately for sure.

OP posts:
JMAngel1 · 18/05/2023 19:59

Saw Palmetto supplement first.
If not helping possinly spironolactone from a dermatologist

WhereAreWeNow · 18/05/2023 20:03

What HRT are you on? I'm in the same boat. Was on Dianette for years. Some forms of progesterone are androgenic and some not.

HisHobbyIsSex · 19/05/2023 10:54

WhereAreWeNow · 18/05/2023 20:03

What HRT are you on? I'm in the same boat. Was on Dianette for years. Some forms of progesterone are androgenic and some not.

I'm on estradiol, it's the Oestrogel form 4 pumps daily. I'll try saw palmetto.

Adding another medication in (I also take antidepressants) makes me worried about weight gain, which I also don't want....

OP posts:
HisHobbyIsSex · 19/05/2023 10:56

JMAngel1 · 18/05/2023 19:59

Saw Palmetto supplement first.
If not helping possinly spironolactone from a dermatologist

I'll try saw palmetto thanks. Any tips on brand to get?

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WhereAreWeNow · 19/05/2023 11:37

What progesterone are you using @HisHobbyIsSex ?
Be careful taking supplements. I've read that saw palmetto affects estrogen receptors so can reduce effectiveness of your HRT. Check with your GP before taking it.

JMAngel1 · 19/05/2023 11:38

I got one from Amazon called Nature’s Aid think it’s about £9 and worth every penny!

HisHobbyIsSex · 19/05/2023 13:27

Yes I just read that saw palmetto can interfere w hrt.
I do not take any progesterone. I have mirena coil for womb.

OP posts:
highfidelity · 19/05/2023 13:32

HisHobbyIsSex · 19/05/2023 13:27

Yes I just read that saw palmetto can interfere w hrt.
I do not take any progesterone. I have mirena coil for womb.

It could be something as simple that you need more progesterone than your mirena provides, rather than an anti-androgen.

Either way, go see either a woman's health specialist or a gynae. I went to see the former and they were a god send for sorting my HRT needs out when many a GP had failed.

JinglingSpringbells · 19/05/2023 14:21

Don't dabble as some herbal products are not safe when mixed with other meds.

And many are just snake oil.

Make an appt with a BMS registered doctor who can guide you as you are already on HRT.

WhereAreWeNow · 19/05/2023 17:33

I believe the progesterone in the Mirena is a more androgenic one. If you're having lots of problems, it might be worth talking to your GP about switching from Mirena to a less androgenic form of progesterone. I found a table once of all the different types of progesterone and their androgenic properties but I can't remember where.

HisHobbyIsSex · 19/05/2023 17:57

WhereAreWeNow · 19/05/2023 17:33

I believe the progesterone in the Mirena is a more androgenic one. If you're having lots of problems, it might be worth talking to your GP about switching from Mirena to a less androgenic form of progesterone. I found a table once of all the different types of progesterone and their androgenic properties but I can't remember where.

My understanding is that mirena is so localised to the womb it doesn't have a systemic effect. Will investigate further. Thanka

OP posts:
largeprintagathachristie · 19/05/2023 21:46

I paid to see an endocrinologist privately. Menopausal and have PCOS. I was getting serious hair loss, which was always my PCOS symptom, rather than excess hair. Was on dianette for years but had gradually been advised to withdraw all anti androgens because of age and that PCOS was “over”. It wasn’t.

GP was no help, menopause clinic was no help; doctor there said my hair loss was probably seasonal, and then swished her long thick hair around. Instead of talking about my hormones, which is what I thought I was there for.

All that took months to get nowhere and I went private out of desperation.

Chipswithketchup · 19/05/2023 21:56

I had Spironolactone prescribed privately from a dermatologist, who really helpfully wrote to my GP & told them to put it on repeat prescription. Taken alongside HRT it works brilliantly for me (I was on Dianette for years & loved it but am sadly now too old).

HisHobbyIsSex · 20/05/2023 10:09

Chipswithketchup · 19/05/2023 21:56

I had Spironolactone prescribed privately from a dermatologist, who really helpfully wrote to my GP & told them to put it on repeat prescription. Taken alongside HRT it works brilliantly for me (I was on Dianette for years & loved it but am sadly now too old).

Any effect on weight?

OP posts:
HisHobbyIsSex · 20/05/2023 10:10

largeprintagathachristie · 19/05/2023 21:46

I paid to see an endocrinologist privately. Menopausal and have PCOS. I was getting serious hair loss, which was always my PCOS symptom, rather than excess hair. Was on dianette for years but had gradually been advised to withdraw all anti androgens because of age and that PCOS was “over”. It wasn’t.

GP was no help, menopause clinic was no help; doctor there said my hair loss was probably seasonal, and then swished her long thick hair around. Instead of talking about my hormones, which is what I thought I was there for.

All that took months to get nowhere and I went private out of desperation.

Yes, i am not even bothering with thr nhs. What did your private endo give you?

OP posts:
TeSe81 · 20/05/2023 15:27

And can I ask what did the private specialist concluded?

TeSe81 · 20/05/2023 15:31

largeprintagathachristie · 19/05/2023 21:46

I paid to see an endocrinologist privately. Menopausal and have PCOS. I was getting serious hair loss, which was always my PCOS symptom, rather than excess hair. Was on dianette for years but had gradually been advised to withdraw all anti androgens because of age and that PCOS was “over”. It wasn’t.

GP was no help, menopause clinic was no help; doctor there said my hair loss was probably seasonal, and then swished her long thick hair around. Instead of talking about my hormones, which is what I thought I was there for.

All that took months to get nowhere and I went private out of desperation.

Oops, my question was directed at you. I’m interested to know whether an endocrinologist finally brought the right approach to your case. I hope you’re doing better now?

largeprintagathachristie · 20/05/2023 17:26

TeSe81 · 20/05/2023 15:31

Oops, my question was directed at you. I’m interested to know whether an endocrinologist finally brought the right approach to your case. I hope you’re doing better now?

@HisHobbyIsSex

Here's more info. I'm 51, for reference.

I researched private endocrinologists and picked one that specialised in PCOS, amongst other things, and seemed very well regarded. He turned out to be a really nice man, too, and I was so relieved by the time I walked out of the consulting room. I wasn't imagining the hair loss, I wasn't imagining the acne (both of these were a resurgence of PCOS symptoms, which had been really well controlled most of my life due to Dianette and other anti-androgen therapy, such as spironolactone and finasteride. )

My periods had come back, though, in my late 40s, despite stopping Dianette and my skin and hair were ok, so I'd thought PCOS was over and I'd really taken my eye/mind completely off it. Photos of me in 2018/19 have lovely hair! A few years later I attributed hair thinning to menopause, generally, (not connecting it at all with the fact that a menopause specialist in 2020-ish had recommended stopping my remaining anti-androgen, which was spironolactone. I started oestrogen patches but wasted, gosh, two years, really, with higher and higher doses being recommended by the menopause specialist. I kept thinking, maybe things will improve if I just get more oestrogen!

My recent diagnosis with the Consultant Endocrinologist was androgenetic alopecia. He prescribed spironolactone 100mg twice daily and said I'd know within six weeks if it was helping, if my acne (cystic spots on chin) improved. My skin did improve, massively, and really quickly. So that's good.

The hair on my head, though, is another story. The doctor explained that my current hair had grown under really poor conditions, with an androgen dominance, and couldn't be "fixed" - I just need to hope that later hair cycles in a year or so improve. It's a bastarding thing. I guess the changes happened so slowly and gradually I just didn't cotton on that it was happening. And it will take an equally long time to potentially improve.

I also discussed HRT with the Consultant.
I'm now on Oestrogel 2 pumps a day (turns out I wasn't absorbing the bloody patches!) and for the progesterone element, I take cyproterone acetate.
Cyproterone acetate is a further anti-androgen which is also a progesterone.

Usually used in men with prostate cancer but also in treatment of women suffering from disorders associated with androgenization, eg, acne or hirsutism.
GPs won't be comfortable prescribing it and it's left my GP in a kerfuffle, despite not being able or bothered to give me one iota of help when I first went to them.

I've asked to be referred to NHS Endocrinology but there's a nine month wait for that.

Good luck to all of you who are working through any of this type of thing.

HisHobbyIsSex · 23/05/2023 21:04

@largeprintagathachristie - v helpful. May I pm you please for the details of the endocrinologist you saw?

OP posts:
largeprintagathachristie · 24/05/2023 07:11

HisHobbyIsSex · 23/05/2023 21:04

@largeprintagathachristie - v helpful. May I pm you please for the details of the endocrinologist you saw?

Yes, of course, that’s fine

HisHobbyIsSex · 24/05/2023 16:52

largeprintagathachristie · 24/05/2023 07:11

Yes, of course, that’s fine

Thanks, I have pm you.

Plot twist, I have been asked how long I've had Mirena coil in, and its 4 months shy of the 5 years, so I wonder whether the amount of progesterone is tailing off from that.....

OP posts:
Chipswithketchup · 24/05/2023 18:57

HisHobbyIsSex · 20/05/2023 10:09

Any effect on weight?

None at all, weight stayed the same.

Timefortea123 · 02/03/2025 19:44

Apologies for resurrecting an old thread, but can anyone recommend a private endocrinologist to help with my ongoing pcos/menopause/ androgenic hair loss? Did anyone from this old post find some solutions for effective anti androgenic medication? I too had my best hair when on Dianette for pcos(many years ago) and am now on HRT patches and mirena coil. Hair loss getting steadily worse. Convinced PCOS still at the root of hair loss even though I am menopausal. Gone down the dermatologist route but all very unsatisfactory. Any advice appreciated, many thanks

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