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How long for Genetic test results? (Coping with waiting/ DH in denial)

12 replies

ImontheTRAIN · 23/10/2019 16:50

These are being done in Leeds. Its heart breaking having to wait and trying to second guess all the time what condition(s) may or may not be affecting DS (11 weeks.) Google is being searched on overdrive in our house, DH is in denial of any issues. I'm really struggling at the moment. I want you all to share your experiences and diagnose my DS, even though I know how ridiculous it is; and no doubt irrational, to expect my lovely fellow MN'er's to give me a clinical outcome over the internet.....

It was picked up at birth that DS had issues with his tone, small jaw, high arched palette, struggled to open his eyes, dysmorphic features. We've had so many appointments. Initial blood tests for DiGeorge syndrome (22q11 deletion) have come back negative but a 'possible genetic imbalance' has been found. It's pretty obvious to me that there is something not quite usual (should I use the word 'normal'?) with gorgeous DS, DH hasn't had children before so he has no point of reference, but its so tricky not being able to discuss things with DH fully as he is getting very defensive. I want to be able to talk to somebody about the fact that I'm fearful about what the future holds, I'm scared DS will be bullied, that he won't live a healthy fulfilled life. Then I chastise myself that just because children may have additional challenges, it doesn't mean they are not happy, content, settled. We'll do the very best for him regardless. I'm in tears and feeling isolated as we are in limbo whilst waiting for further testing.

Hearing and sight tests have come back normal, as his MRI scan, thankfully. But DS had a hip scan today and they had a lot of problems getting his leg to bend as he was tensing his muscles so much. DH said it was because he was cold eye roll He has Hypotonia and the consultant has said it is 'fact' that he'll have GDD. DH now denying the consultant has a credible education due to the fact he is from abroad. DH isn't usually such a dick, and ironically, he is from the same country as the consultant!!

DS isn't smiling, has a very odd shaped head, 'vacant' look in his eyes, avoids eye contact, cries a lot, large low set ears, high forehead, small jaw and tongue, really cannot hold his head at all (significant head lag) However he feeds well, follows objects and yesterday rolled over by himself which I was so proud of.

DH was told he'd never have children. DS is the result of ICSI and really is a miracle baby - we have three embryos frozen and now need to think seriously what to do with those.

This message is quite disjointed and I do apologise for that, I think my thoughts are a mess. No family to talk to about all this. I think I need a very un-MN hug

OP posts:
hazeyjane · 28/10/2019 08:37

Hello
I wrote a great long post in response the other day....and lost it!
This one might be a bit shorter!!
Years ago when ds was about 10 months old, I started a thread called something like 'The Rocky Road to a diagnosis' - there were a small group of us whose children had all had difficulties since birth, and were going through testing and trying to set up support. It really helped me at a time when I felt very alone in it all.

No one believed there was anything wrong with ds until he was 9/10 months old and then it became very apparent that he was not following a typical path of development- he couldn't sit, crawl, roll, had head lag, didn't play, didn't babble, couldn't eat, screamed with awful reflux and rarely slept. To me his hands and feet looked odd, his fave looked slightly different to his sisters, he had a tiny ear pit, his tongue was odd.... things that niggled suddenly became hugely significant when professionals started listening to us.

Ds had MRIs, Blood tests, we met with neurologists, geneticists, paediatrician, physios, SALTs...I told about a million people what his birth was like (terrible), all our concerns, all the things ds didn't do. It was fucking horrible and scary (he was tested for some life limiting and degenerative diseases) and also a huge relief - because finally someone was listening.

The geneticist decided that ds 's issues were as a result of a genetic condition, it was then a case of which one...she described this as trying to find a spelling mistake in a book in the British library. First tests were for the easy to test and most obvious candidates and the most scary ones. Everything came back negative, the geneticist warned us this could take years, and some adults still don't have a diagnosis.

When ds was 4 he was put into 2 studies, one in Holland for a condition he had lots of markers for and one called the DDD study (Deciphering Developmental Delay - this study closed.... Still no results. At 7 He was put into another study, the 100,000 genome project (still open). Then when he was 8 his geneticist called us and said to come in. In all honesty we had given up hope of a diagnosis. The DDD study showed that d's has a very rare genetic condition. She told us to look the other parents up on Facebook, or start a group - there are about 70 children worldwide.

I know children still in the group I started on here and in real life who still have no diagnosis, some with quite profound disabilities. Being undiagnosed is far more common than people realise. There is a group called SWAN (syndromes without a name) who have a very active Facebook group.

Despite no diagnosis until 8, ds has had a lot of input from professionals - portage (the best thing ever), DLA from age 1, 1-1 funding at preschool, EHCP at school, a place in a Complex Needs Resource Base. Since a diagnosis things have been easier, even though support is supposed to be needs based. It was like finally having a torch after years of being in a fairly murky room. I have also found families who have children very similar to ds, and contacted the Dr after whom the condition is named. For some friends getting a diagnosis made little difference - they are almost unique in their genetic mutation and so they have a series of numbers that give them the glitch but otherwise nothing has changed.

The most important thing is accessing the support that your ds needs. Make a note of when everything happens (I have a timeline!). Make up a "passport" - a one page profile that lists any difficulties your child may have, any medications and important professionals. Get portage as soon as old enough (Google portage and local area). Go to baby groups if you can, do not be afraid of seeing other babies develop differently....your baby may be on a different path, but it will still be a journey filled with wonder. Find things that engage your baby....water, lights, messy play, singing. Learn some Makaton (your child may have no speech difficulties....but signing is fantastic if they do...and fantastic if they don't!)

hazeyjane · 28/10/2019 08:37

....blimey that was longer than i thought!!

hazeyjane · 28/10/2019 08:42

....oh and I'm not a hugger....but HUG

itsgettingweird · 30/10/2019 18:48

My ds had a CHG array and it came back after a few months. Clear.
Brain and spine mri clear.

Specific blood test for something called HSP took 10 months to come back.

He's heterozygous for a genetic mutation. It's one if the HSP genes. But his gene variant has never been reported before.

Now waiting for genetics who will decide if it's the syndrome (has all symptoms) or something different.

He's 15!

Just make sure that you record everything and make notes of questions to ask and of anything that's said. Cannot write the process better than Haley (waves!) and I know she's very knowledgable and has actually supported me in this.

Genetics is a minefield but it's also an area with heavy investment atm so hopefully they'll keep trying genetic tests and studies.

hazeyjane · 31/10/2019 09:24

to itsgettingwierd....I hope you are on the way to some answers for your ds. I think as time goes on your attitude to being undiagnosed changes, then when an answer (or even anothet piece of the jigsaw puzzle) comes it can hit you like a comedy anvil again!

In a wierd coincidence...the day after posting on this thread, I got a letter from the 100,000 genome study the first part said it confirmed his diagnosis from the DDD study, the second part said that further results may be pending and will come separately ..... BADOING!! Another 'What If'... I felt like I'd been smacked in the face!

Another thing I meant to say in my first post @ImontheTRAIN (but it was longer than my thesis...so I forgot) - is that there are lots of levels of genetic testing, there are specific tests for individual conditions (like DiGeorge, Prader Willi etc) then there is a micro array, a CGH array, a FISH test....ds had all of these over the years and all came back negative - he still had a genetic condition. The technology has advanced massively in the last couple of years, and the new studies look at whole exome sequencing. It is like using a home telescope to start with, that allows you to pick out individual planets, then moving onto the Hubble telescope and being able to identify whole new galaxies.

So another thing I would do is ask about being put on a study.

Themazeoflife · 31/10/2019 09:33

Have you looked at Turners Syndrome. It's very rare in males.

hazeyjane · 31/10/2019 09:56

It's difficult because there are literally 1000s of complex genetic disorders (mutations in more than one gene) chromosomal disorders (missing, extra or mutated chromosomes) and single gene disorders (mutations of single gene) - and within each of those conditions a huge spectrum of how a person is affected. Some of these diagnoses have only come about in the last few years as a result of the advances in genome technology, some have names (after the Dr(s) who finds them) the majority are a series of numbers and letters. Some are 'de novo' (ie habe arisen out of the blue) and some are familial (which is why the studies ask for cheek swabs from family members)

There used to be a mumsnetters who worked in genetics, I will try and remember her name - she explained things very well. (I am very lucky to have become friends with my ds's former genetics nurse...who gave me an idiots talk through!)

It is very hard to stick a pin in a map and land on the right genetic issue. However a good geneticist can often look at a child's dysmorphic features (even very mild ones) and clinical features and come up with an idea.

In the USA they are developing technology to "read" a child's features that can then lead to correct testing.

At present though, long term (ie can take a while for a diagnosis) studies using whole exome sequencing is the most accurate and fastest way.

itsgettingweird · 31/10/2019 17:49

Ds neurologist who is involved in 100000 genomes told me that he's recently been to a conference/ meeting and that if the wrote all the dna mapped out in the smallest text then the book would be an inch thick.

And 137 volumes Grin

From just 22 chromosomes.

My ds is heterozygous for the BSCL2 gene. He has all the symptoms and signs of the HSP disorder related to this gene.
But a completely different missense gene which produces the wrong wrong protein (iyswim) rather than the wrong protein usually recoded.

It's just a case of genetics deciding if his variant is causing his symptoms. (But both neuros and me don't see how it can't be. But genetics have to confirm this!)

Hope whatever else they have for you hazey doesn't come as too much as a shock. With ds there are other conditions connected to his gene variant - but he doesn't have the signs and symptoms for these.

Themazeoflife · 05/11/2019 21:06

I forgot to say, my DC results took 6 months as it showed up something they had never seen before so they re did one test and added something else on.

AdamantEve · 15/11/2019 08:42

Hi, just wanted to reply as in a similar position to yourself, we’re waiting for genetic test results for DD who is 23 weeks. Ours are being done in Manchester and we were told a turnaround time of 6-8 weeks, it’s been 2 weeks since the bloods were sent off. Currently spending everyday feeling like I’ve been pushed into a black hole. Nothing was picked up at birth with my DD but like you, I have older children so it was obvious to me she was not quite “right”. I hope you get your sons diagnosis soon, I’m also in google overdrive so understand that!

AdamantEve · 15/11/2019 08:45

How was your experience with the MRI scan if you don’t mind sharing? DD is due to have one and I’m nervous about the sedation even though that should be the least of my concerns right now.

ttrrii · 14/09/2022 21:50

Do you have any answers or updates?

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