@sleighbob As far as I am aware the grade will not get disregarded at all. It is hardly the choice of the child when they sit the exam. I will ping @poetryandwine who is a former admissions tutor who can clarify.
But I think the key thing here is 11 other subjects suggesting that she is taking 12 GCSEs in total. Most state students take 9. Ds was hot housed for single sciences in year 11 so took 10 in total. Ds1 is in a top 10 uni with a mere 9 GCSEs.
9 GCSEs as standard consists of
English lit,
English lang,
maths,
science which gives you 2 GCSE grades
then 4 options to choose subjects.
If they offer triple science which gives individual grades for each science then that is an option subject choice and gives them 3 remaining options. Language is encouraged as is a humanity, whether History, Geography or Religion, Philosophy and Ethics, that then leaves 2 as standard or just 1 if triple science.
12 subjects seems excessive to me but then I only have experience of state schools. As you mentioned uni, what is the sixth form like? Again you only need 3 A levels and the vast majority of A level students take 3, even for medicine. A very small percentage take 4 and at least half of those are for Further Maths.