DC is only in Y8 but options are coming up next year. She is in the top set for science at a large mixed comprehensive - predicted grade 7-8 I think, but I don't know how meaningful that is at this stage - and the school encourage the top set to take separate sciences.
DH is very keen for her to take separate sciences, in part because as like me he went to a selective school that considered combined science to be very inferior, and in part becuase he is in a scientific career (of sorts). I am ambivalent - I did 3 sciences, & it was utterly irrelvant to my future academic life, & they get so few options I can see it would be good to have another option free by taking combined science!
DC has no idea what she wants to do when she is older - drama, farming, archeology all get mentioned - so some sort of scientific career can't be ruled out, but is it really significant if she hasn't got the separate sciences at GCSE? I've been told that you can pick up the A level subjects without having done the separate sciences...