Absolutely Brisklady.
DD did not apply to Oxbridge as she wanted a medical degree with a more hands on approach. Similarly we have known people opt for the Courtauld for History or Art, Northumbria for Product Design, and so on. One of DS' peers went straight into acting, another into Forumula 2 racing.
A good number of their peers who did not get places at Oxbridge despite applying, were aiming for the more competitive degrees: Cambridge NatSci, Engineering, and Economics, or Oxford E&M or PPE, and and medicine at either, and preferred to go elsewhere rather than opt for a less competitive subject. And certainly for DS and some of his friends their preference for Cambridge over London was not that large, if it existed at all.
As a pp suggests, the school put a lot of emphasis on pupils doing their own research into courses, and not automatically assuming that Oxbridge was the be-all and end-all.
I do not see them not getting Oxbridge places as a failure of the school. Instead I see it as a sucess that both went to University well prepared for the step up and the different style of study.