Equally, however, I have (English lit, my subject, is the first grade),
4a, 6a - A levels a, b, c, failed to meet conditions of offer from Exeter, went to Cardiff in clearing, to do Lit...
6A, 4A, 1B, at private school, got A, A*, A, off to Oxford
4A, 4A, B, C, got A, B, B, gone to do a foundation degree in Art at Leeds
5A, 6B, got A*, A , B, off to Bristol to do Lit.
There are various others. I think all you can see from all of this is that GCSE is at best a precarious guide, and as I mentioned way back, my son got only 7 A-C - no As, and 2 Ds - got ACUU at AS, and still got offers from all 4 RG unis he applied to - and got A, A, A, A at A level.
I truly think that anyone reading most of your responses here would think that universities set huge store by GCSE grades, and my experience as a sixth form tutor and a parent suggests they don't. I would hate anyone reading this thread to look at DC's grades and decide they should lower their sights. The thing that matters most of all is predicted (not target) grades, and the personal statement.
Students should go to open days and discuss it with admissions tutors if they are concerned. One poster said it would make no difference, but firstly they give great advice - eg that dual honours gave less flexibility in the choice of modules - and the three that DS visited made offers within a week, and all three tutors wrote down his name and notes about him. If, like him, you are more impressive in person than on paper, it makes sense to meet them. When we went back for induction, the tutor also remembered a lot of his personal statement. A good personal statement is way up there above pre-16 grades, in my opinion.