Have you tried couples counseling?
For one, I don't think that every disagreement or bad mood should lead to saying we need to separate or go on a break. If she means it, then your relationship is in very deep trouble. If she doesn't mean it, she's being manipulative. Either way, it's bad.
Second, you're bringing up a few rather vague things like how 'she doesn't have manners' or she will 'guilt trip' you and 'kick up a fuss'. These are your interpretations of what's happened. This is the label you put on it, not the actual behaviour on her side, nor the context in which all of this is happening. It's very clear from your post that you feel like the victim of her moods. And I'm not saying you aren't, you just haven't given us much actual information to work with.
If she is behaving irritably the majority of the time and not communicating about the underlying reason, then that's obviously not the best way to go about things.
However, without excusing her behaviour, have you just decided that she's unreasonable and in a bad mood for no reason whatsoever? Or have you wondered why? Has she maybe tried to communicate how she feels in the past? If so, how have you responded to it?
I'm not saying this is definitely the case in your situation, but I have a feeling you're seeing yourself as the victim and you're seeing your wife as the offender. That takes away every bit of responsibility and accountability you have in this dynamic. It also ensures that you have zero willingness to actually listen to the concerns and maybe valid criticisms your wife has to share.
Again, this doesn't take away the fact that your wife shouldn't be communicating this way either, but you're probably both pointing blame at each other rather than seeing it a a shared problem that takes effort from 2 sides to handle.