I love having an en-suite! TBH it's not any noisier than using the hall bathroom. Half the time there's a bathroom next to the main bedroom anyway, just no door, so it doesn't make that much of a difference sound wise. I go in there and relax in the bath. The children can't annoy me and they have another bathroom to go use.
also don't love full open plan. I don't want all my rooms closed off with doors (that was a change moving countries, Americans almost never put doors to the kitchen, dining room, living room) but I don't want one massive room so everyone can see the mess in the kitchen at all times.
US specific: I want my laundry on the ground floor. Older homes in my part of the country have them in the basement, most newer ones have them by the bedrooms. Upstairs may save bringing it up and down stairs, but then you can't run it at night!
Will not do again: anywhere without direct access from the main living area to the back garden. Here, when a home is built on a hill, the front entrance is the main floor, but it slopes downward so there is a flight of steps down to the garden. Even if there's a deck directly off the door, it really impedes my enjoyment of outside, and I have to maintain the deck. Maintaining a patio on the ground is much easier.
I will not buy a house that needs work or anything with a swimming pool unless I have heaps of money. Same for a massive garden. I don't have time or energy to spend half my weekend gardening from April to October.