This is the crux of it.
For me the gold standard is megaflo, ie pressurised system boiler (boiler with tank). This produces lots of hot water than can be drawn on instantly at mains water pressure. So good if you have multiple showers required at once and you don't want those showers to vary in temperature.
I would say the main disadvatages/advantages of the combi boiler are :
Can remove hot water tank to give you more space.
Is generally cheaper to run for fuel as you can maintain different temps for hot water and cold water and you only heat the hot water you need when you need it.
More hot water lag (time to deliver to the tap) unless you have preheat, which reduces efficiency.
Probably lasts for less time, as fires up more so lifetime of boiler is reduced.
Cannot deliver as high hot water flows as a system boiler.
Hot water delivery becomes sensitive to the entire system, ie someone turns on the sink hot water and the shower hot water may cool down.
I think you should also think about the style of your house, in a luxurious house people expect better services, so you really want to go for gold standard like megaflo which will deliver hot showers at high flow rates with no variability, but will cost more money to install. A combi boiler is fine in a cheaper budget house.
Also I don't know anyone who brushes their teeth with hot water. And it makes no sense to have electric showers if you have a good system boiler to me as they are a lot more expensive compared to gas (3x the price) and don't deliver as good flow. The only use for them to me is for backup if the boiler goes down (if you have a system boiler you will almost certainly have an immersion heater backup so don't really need this) or if you are putting them in a place where it is difficult to route hot water plumbing.