Hi again all
Thank you SO much for rallying around as you did. This was one of those situations that unfolded and, at the end, you say to yourself 'if I'd known xyz at the outset then I'd have called someone to do it'. 10-12 hours all told across the weekend with skinned knuckles, cut fingers, broken drill bits and enough swearing to turn the air blue.
I eventually went with the drilling-out solution involving a 2mm pilot hole followed by a 6mm. One worked reasonably ok but the other went badly off-centre and i had to resort at the end to snapping the remainder of the screw-head away with pliers and a mole-wrench, luckily enough of it having been drilled away by that time.
And then on Saturday evening, just at the 11th hour when I thought it was sorted, I found out the hard way it wasn't. Silly me thinking 'no need to put any of that silicone stuff in like the previous people did - surely the rubber washers that came with the replacement valve assembly will be watertight, won't they?'
WRONG!
So I had to get silicone then go back there on Sunday to partially dismantle the toilet and put some silicone in to seal it properly. This should have taken 30 mins-1hr at most. But guess what? While unscrewing one of the 2 coupling bolts, the wing nut fell off and vanished into the space under the toilet bowl and trying to retrieve it took me another 2-3 hrs.
Last issue - the fill valve is a Fluidmaster bottom entry one with a brass shank, attached by a brass bolt to a braided flexible hose running up into it from the isolator. As you can imagine, access to it is extremely tight - pretty much like this and so I couldn't get a spanner or mole-wrench in there, only do the brass bolt up finger-tight and hope that the washer in the bolt stops it leaking. Which it seems to have done so far but I'm not happy about it. But - with the flexible hose running up into it, I can't get a box-spanner in there either.
Any suggestions?