Declutter asap- be ruthless.
Use smaller boxes and label everything clearly. It makes it all more manageable and your removal people will be grateful.
Pay for the best removal setup you can and/or rope in friends and family if they're going to be practical and useful. Send kids to stay a night or two with someone if possible.
Get all your laundry up to date and change your bedding a couple of days beforehand. On the day, place your pillows on top of your made bed and roll everything together so that the underside of your bottom sheet is on the outside. Set your beds up first and simply unroll bedding into place. That way when you've had enough you can go straight to bed.
Pack a weekend case for each of you with everything you need for at least a couple of days including toiletries and towels. Take it with you in the car and leave it there so it doesn't get lost amongst the boxes- fetch it in once you've made the bed.
Bundle hanging items together by taping the hooks and covering with a bin bag- poke a hole through the base with the hooks and cover it like it's dry cleaning. Leave clothing in drawers, just tape a pillowcase or similar over them so the stuff doesn't fall out.
Big blue IKEA bags are great for moving pots and pans and general stuff.
Put a box together with bathroom cleaning stuff and loo roll in a plastic bag, do the same sort of thing for the kitchen.
Create an essentials box which travels in the car with you. It should contain the kettle, cups, stuff to make drinks, crisps/healthier snacks and easy fruit- apples, grapes, bananas etc (you will get sick of eating crap which will make you feel worse when you're tired).
Then add in binbags, chargers, screwdrivers, a hammer, sticky tape, hand cream and a bottle of whatever makes you happy.