No, not if it was a smallish drop like 5-25k (though what is small might depend on your area). In fact, I'd find it encouraging, more likely sellers open to discussion.
If it's a huge to me drop, like 50k or more, I might wonder if some big issue had been found, but I'd likely still ask about it if it suited our needs (keen to move into a more accessible house) especially at the moment with so much ambitious pricing going on in my area, possibly brought on by headlines of booming prices elsewhere or HMO landlords wanting to recoop costs. The latter was an issue for us yesterday, even the lovely estate agent seemed frustrated that there had been a lot of interest and even offers on the place, but the seller was only accepting full asking price 'as he's already reduced once' (she had already talked up a different, significantly cheaper property she'd just got on her books - that should have been a sign. Lovely kitchen, but every other space needed a lot of work, even signs of water damage and a lot of mold plus it looked like we'd have to remove a lot of tatty HMO furniture, on a house 20k higher than the most expensive house to sell in that postcode. Great area, but the wrong one for the price that seller wants).
Alongside the lingering HMOs, there have been a few nice family homes that I can't help wonder if their estate agent knows the area the house is in (like a 1/4 mile up the road in a different district and catchment area might fetch certain prices, but not the one they're in). One - with the worst, most patronizing estate agent - even put up the price 25k after we'd had two viewings!
Literally, the price was one in the morning, and when we came home after - it had changed. A house that had been on the market for several months and failed to get any bids at auction (but with the 28 day thing and how things are, a lot aren't) We were already put off by having been discouraged from getting a survey - asshole agent actually asked me if I knew structural surveys could be up to a 1k around here for a house well over 100 years old...I can only imagine what worse is hiding behind that new paint job.
Many things are more off-putting than reducing a house price again.