I've done it for 15 years. I was relocating to be with my partner, and my house wouldn't sell. Some years later, we were able to save enough to buy without having to sell the rental house to fund the purchase so we've carried on being landlords.
Longest void period has been 3 months. I've had to evict one tenant, whilst pregnant (me, not the tenant), which was stressful but luckily had rent guarantee insurance which covered the costs and the unpaid rent - so I second the recommendation to pay the modest cost of the premium for that peace of mind. Two other tenants have left the house in a less than great state. The other 3 have been absolutely great.
I manage it myself and just use agents for the initial letting process.
Having rented out what was formerly my home, I found the hardest thing initially was detaching emotionally. The second hardest thing was constantly feeling on the wrong end of the deal as both landlord and tenant (while we were renting ourselves) - somehow we were always the ones who ended up doing the end of tenancy cleaning, whether it was the house we were renting, or the house we were landlords of because our tenants hadn't done what they were supposed to.
Will you be returning to live in the house at some point? If not, what is your long term plan - if you intend to sell eventually, can you afford to cover the mortgage and overheads as well as renting in your new area, while it's on the market? It can be harder to find a buyer when the house is empty because you're living elsewhere so bear that in mind.