I live in a gorgeous house on a main road. We moved here because it was on the main road, we are very rural and when we were house hunting we couldn't get to a couple of the houses we were meant to see which put us off a bit because we had to get to work.
DH had a job where he was on call and had to get to work within 40 minutes if ever the phone rang.
We tried to sell earlier this year - on the market for 10 months, plenty of viewings (2 or 3 a month) and no offers. Feedback generally said that the road (40mph) was an issue.
You can't hear the road in the house as it has 2ft thick walls and double glazing. Gardens are lovely but we don't use the garden next to the road, we grow vegetables, mow the lawn and have a climbing frame in it. We use the other three sides of garden.
Have a stone wall in parts, tall fence and a beech hedge inside all of that.
I think that you will get used to it - no doubt about that. I love our house but in hindsight I wouldn't buy it again, just because it is harder to sell a house on a road.
TBH, we didn't even think of the negatives when we bought, we could see that you couldn't hear it inside and we knew that we had to get to work (DH on a really strict timetable).
Just the selling on factor really for us.