I spent many, many ocd hours on our kitchen layout and ended up ignoring loads of advice about layouts and runs of worktop space in order to get something designed for exactly how I use space. I love it and it totally works for us - gets great comments from visitors too.
For example, lots of advice says to have a long run of worktop where possible. I chose instead to go for discrete areas, so there is an 80cm area where the kettle & drink making area is, and that is opposite the fridge and not near my food prep area. This means dh doesn't get under my feet and his coffee-making detritus doesn't spread everywhere and we can share a kitchen without risking unauthorised use of the knives.
I also know that I tend to clutter up space but work well with tight boundaries. I can keep each "everyday" space clear well with our layout, but I know a long stretch would end up getting squeezed down to a tiny one by stuff accumulating. So my kitchen might not work for anyone else at all!
We have on one side an extra deep worktop (on mumsnet advice) with:
80cm for drinking making, getting stuff out of the microwave etc.
100cm between the sink and the hob for food prep and dirty dishes.
50cm on the other side of the hob for serving up (this is a bit tight, but is right next to the table anyway).
This side is always clear if I am not ill or giving birth or such. Dh doesn't DO clearing up because he doesn't apparently SEE mess. (rant over)
On the other side:
180cm normal depth beside the built in oven - mainly is my baking area - space to do pastry, get gadgets out etc. Also gives home to the toaster and fruitbowl. This gets more cluttered but doesn't affect churning the meals out as much so I can cope.
Also, 120cm narrow worktop over a floor-level wall unit which is for post, filing, whiteboard & calendar over it, radio, chargers for phones etc. This also is cluttered at the moment and useless because dh didn't realise that looking after the house while I was very pg, giving birth and struggling with breastfeeding also meant looking after the paperwork... When we're on top of that, it is a REALLY useful space.