Hyperemesis - when to take meds?

[Marfs10]

I posted a couple of days ago about being prescribed cyclizine, lots of helpful responses and advice - I did end up getting admitted for fluids and came out feeling infinitely better, albeit short lived.

Ive now got 3 different meds, Cyclizine, Prochlorperizine and Ondansetron*, and have just been told its trial and error but I can take all 3. I’m quite uncomfortable about taking meds at the best of times but this feels mad, how do I know when to take what? Would anyone be willing to share the schedule that worked for them?

*i know about the risks of Ondansetron, and have balanced the risk mentally. I have every intention of going back and asking for Xonvea tomorrow if I don’t see any improvement today.

Thanks

Hopeful bump

I'm 10 weeks and I'm on xonvea and ondansetron (max dose for both). Speak to pregnancy sickness support they can help you understand how much of which drugs you can take and how far apart.

I currently take
6am -8mg of ondansetron and 1 xonvea tablet
12noon - 1 xonvea tablet
6pm -8mg of ondansetron and 2 xonvea tablet

It's made a massive difference for me. I still feel sick all day and am pretty miserable but I can at least eat and drink now and I rarely vomit now.

Before I was only vomiting 2-3 times a day but my nausia was so bad that I was bed bound and could only eat and drink half of what my body needed so I was just losing weight and getting slowly dehydrated.

Not sure if this is your first pregnancy but this should improve for you and become more manageable in 2nd trimester. It's truly awful suffering with such bad sickness in the first trimester.

I found taking the antiemetics the moment I woke up helped then throughout the day as soon as symptoms were starting to come back.
I'd probably start with the combination of cyclizine and Prochlorperizine first. I'd so 2-3 days of one first then the other when symptoms return then swap to see if one is more effective than the other.
If that doesn't help swap the least effective one for Ondansetron. Keep a note of when you need the second dose and then preemptively take it 15-30 minutes earlier

I 36 weeks today and wouldn't have got through the first 18 weeks without both Xonvea and the pregnancy sickness support charity, they were amazing and gave me loads of info to advocate for myself when a particularaly unhelpful and brusque EPU doctor refferedt to me being sick 42 times in one day as 'morning sickness' and refused Xonvea because they have 'pathways to follow and we have to try others first'.

Make sure you're aware if you have the same issues that Xonvea IS a first line med and is the only one specifically developed for HG.
That and Ondansetron together were a literal god send for me.

Thank you all. I’ve been in touch with pregnancy support today so hopefully will get somewhere when I speak to the gp tomorrow 🤞🏼