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Original poster

To progesterone or not to progesterone?

26 replies

AiRoo · 30/05/2025 19:19

Hi all,

im 5+1 today after 2 losses (5+3 and 6+5) in 7 months.

this time around my hcg seems to be rising much better and at 20DPO got 3+ on a clear blue.

I am very aware that doesnt mean anything and a lot can still happen, but seeing that 3+ did make me happy.

my GP sought advice from obs and gynae and they did prescribe 400mg progesterone pessaries twice a day.

when I went for scans with my two losses my lining measured 15mm each time, and from trusty google, I’ve read that’s ok?

so…. I have no bleeding, very few symptoms at all actually, bar sweating very easily (sorry if that gave you the ick).

do I take the pessaries as a precaution or do I not try to fix what is (currently) seeming to not be broken.

the gp gave no advice, guidance, nothing. I don’t even know what my progesterone levels are as she refused a blood test. She just heard my anxiety from two losses and next day I got an email saying “pessaries sent to pharmacy”.

any lived or prior experience with this is welcome! Thank you all!

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Mulledjuice · 31/05/2025 13:31

curliegirlie · 31/05/2025 10:05

From what EPU told me, the evidence is for those with repeated losses who are also experiencing bleeding this time round. A bit of me is thinking by then it’s too late then, innit??!

I’m also curious - and the answer is probably nobody knows - what proportion of early losses are caused by low progesterone vs chromosomal issues….what proportion of MCs can progesterone actually help prevent in any case??

Show quote history

Exacrly. The majority of "early" miscarriages are of unknown cause. Certainly progesterone supplementation can't help where it's eg a genetic abnormality kr a clotting issue or one of the other specified causes. But has been shown to help a good proportion of women with a history of miscarriage with no known cause.

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