Anxious to come off Clexane Injections- HELP!

[TSunshine]

Hi all,

So basically after a CP and MMC at 8 weeks. I’m now 13 weeks pregnant (and terrified) with help from Letrozole. Had a low risk harmony test back and found out we are hopefully having a little boy.

I’ve been on progesterone (stopping when they run out) staying low dose 150mg of Aspirin and metformin as I have PCOS as can help reduce risk of gestational diabetes

I did recurrent miscarriage bloods testing but nothing was flagged apart from slightly low vitamin D levels and herterzgous (sp!) MTHFR. My consultant had me on 40ml clexane injections on a ‘might help won’t hurt basis’ and I’m due to run out in a few weeks and I don’t think he will continue to prescribe

I’m worried that the clexane has got me this far- reading some threads ladies stay on them just before birth! MTHFR seems to have links with blood clotting but doesn’t seem to be widely researched on how long clexane should be continued?

any advice please?

Bump

I am also heterozygous for MTHFR but apparently so are 40% of the population.

After I had two consecutive miscarriages at 12 and 9 weeks I suspected blood clotting issues were causing it as blood clotting runs in my family. I was lucky enough to see Dr Rai at St Mary's hospital, he found heterozygous MTHFR - which he said wasn't a cause as it's so common - AND he found homozygous (both genes are faulty) for PAI-1 which he said was potentially the cause.
So my understanding is that not having a working PAI-1 gene puts me at risk of recurrent miscarriage (and 40% higher risk of blood clots) but the MTHFR doesn't.
I have been put on clexane for the whole pregnancy based on the homozygous PAI-1, not the heterozygous MTHFR.

This is quite useful:
www.healthline.com/health/mthfr-gene
Its important to remember with heterozygous anything you have one faulty gene but also one gene that will work well!

I can imagine the anxiety though about coming off anything after feeling like this pregnancy is finally working. Good luck

Has he said he won't let you continue?

I'm not on clexane but another blood thinner on a "let's see" basis after my RPL tests showed slightly positive for blood clotting. I've not had an issue with getting the injections prescribed and I'm now 29 weeks pregnant.

Seaswimmings may I ask if it worked for you please? Similar boat here, 3 recurrent miscarriages, heterozygous for PAI and homozygous for MTHFR. I was given similar treatment that I am supposed to start next time I get pregnant.

Hi @Carminai currently holding my 6 week old baby boy which feels very surreal after 2 miscarriages. I stayed on clexane injections until 27 weeks and would definitely take them again. Wishing you the best of luck

Congratulations @TSunshine

Yes, it did work for me. I was pregnant when I posted in March and I had twins in May.
I ended up with serious health complications which means they had to be born 7 weeks early but there's absolutely no indication it was anything to do with clotting or Clexane, and thankfully my babies are home and healthy now.

I injected myself with Clexane until the day before my C-section and then for another month or so afterwards.

Best of luck to you and I hope it makes the difference this time