Mthfr homozygous information

[letshope]

Hey all

So as it states above I'm looking for some info on mthfr (homozygous variant)

This morning I've had my results this morning, due to have 3x recurrent miscarriages. 🌈🌈🌈

Has anyone got any advice or success stories in this area? Any treatment they have had or?

I'm reading a lot online and it is baffling and a bit over whelming.

So any help is appreciated. Xxxx

Bump?!? X

Do you mean heterozygous?

It’s quite rare. When is your next appointment with your consultant? They will be able to walk you through what it means for you and what your treatment plan should be.

My understanding is that impairs/prevents vitamin B absorption, including folic acid, which can lead to issues with the embryo.

I’ve just had a deeper Google, there is homozygous, sorry.

It looks like there are two variations, so impacts might be different depending on which one you have.

I hope someone more knowledgeable comes along soon.

Thank you. Yeah I would like to speak to some one and get some more info and things.xx mlm

Hi @letshope
I received my blood tests results this morning and I'm homozygous for the mthfr. I haven't searched the matter yet but I had a full term pregnancy 3 years ago with no complications or birth defects. I hope this gives you some hope for now. I hope you find answers to your questions.

I also have this mutation and have no idea what it really is ! I did google but it was all confusing. I was told it wouldn't be a cause for my infertility issues. But I was diagnosed with a blood clotting condition called protein s deficiency which can cause problems in pregnancy.
Have you had any blood tests done for these blood clotting conditions ?
I am currently 31 weeks pregnancy, naturally, after an ivf miscarriage. I have to inject blood thinners daily but this is second nature to me now.

@thunderonlyhappenswhenits Hey

Thanks for messaging.

Can I ask, on your pregnancy did you take folic acid? If so, higher dose or 400? Xx

Or did you take folate instead?

I've heard mixed reviews?!?!

My consultant is saying to stick with folic?

Thanks in advance xxxxx

I have heterozygous mthfr and been told to take methylfolate not folic acid.

@letshope hi! I've just taken standard pregnacare, before I was taking vit d3 1000 x3 times a day and standard 400 folic acid

@elzober hey!! Can I ask who advised you that??xx

@thunderonlyhappenswhenits thanks hun. I've been told to take folic acid so even though I have an intolerance, the higher dose will build up stores to aid in future pregnancy. I understand the logic obviously but I'm just really concerned xxx

A gynaecologist at a private clinic after I got my test results. I also now take a daily aspirin while ttc. If you have mthfr you can't process synthetic folic acid as well (what they put in most supplements) and it can cause a build up of homocysteine in your system.

Methylfolate is the already processed form so it removes that issue. I also take conception vitamins called Nua Fertility recommended by a Fertility reflexologist which contain methlyfolate rather than synthetic folic acid.

I found this link helpful www.myrelationshipwithfood.com/mthfr-the-mother-f-gene/

I'm just leaving this here, as if someone comes across it looking for hope that I did so many times.

Like the information above said, I've had 3x 🌈 and have been diagnosed with mthfr.

But..... I'm pleased to say I'm now as I type this 25 weeks pregnant with a little boy.

What I done differently...
I took prenatals for 2x months before trying. For me pregnarcare max conception is my go to (still taking them now) reason being these are rhe only ones that are folate based not folic. I also took folate daily 400mg, coq10 400mg and 150mg of asprin. When we tested postive (7dpo) I then took my injections which were enoxparin sodium aka as clexane aka tinzaparin. (All do the same)
The best advice I can give anyone is pay private if you can to get the test done. It was the best £350 I've ever spent. Once we had the results we knew what we could do to try and this also meant we were not waiting 18months to 2 years to see a nhs consultant. Granted once we knew what was going on and we paid for pur injections monthly, which are about £135 a month. But I'm sure whoever is reading this would happily pay that to have a successful pregnancy. Obviously I understand that not everyone can afford it but if you can do it. Don't think about it 2x!

We have been told flippantly by our "now" nhs consultant that there isn't any "official" link between mthfr and recurrent loss....now this is correct, there isn't any link in the UK... BUT there has been MASS evidence in the USA that supports this. I 10000% belive this helped me get to where we are. Before this pregnancy I can hand on heart say I tried every old wives tale, every supplement recommend on here the lot!!! Please don't give up ladies and I wish you all the best in your journeys... love to you all xxx