I am currently 14 weeks with an IVF pregnancy (double embryo transfer, but one stopped developing at 6.5 weeks) after three consecutive miscarriages. No cause was identified for my miscarriages apart from possibly age (41) as a contributory factor so I chose to have CUB screening. NT measurement was fine but overall result came back as 1 in 122 for Downs, so higher risk but lower than the baseline for my age (1 in 71). I opted for NIPT. I asked the midwife before electing NIPT if my result could have been skewed purely on my age, but she didn't know. I also asked if the fact that my pregnancy started off as twins could make a difference. She wasn't sure but she said she would make sure this info was noted. After having the blood test on Tuesday, she has just phoned to say the lab won't carry out the test, because the vanishing twin can give a false result. I'm pretty annoyed I wasn't told this a week ago. My choices now apparently are do nothing or have a amino. After my miscarriages, I'm very reluctant to have an amino based on a 1 in 122 chance, especially as I think it's becoming more likely we would carry on with the pregnancy regardless of the result. However, as the IVF and pregnancy so far have been stressful, I would have liked more certainty. Does anyone know (a) could it be purely be my age that means the CUB screening has come back higher risk? and (b) can the NIPT be done privately perhaps with an adjustment for the twin to give a more accurate result? I'm in Glasgow and I do plan to phone around some places and ask, I'm just waiting until I've calmed down a bit first! Any experience or advice anyone has around this would be really helpful, thanks!