Clexane and high dose cyclogest after recurrent loss

[Sallyjo27]

Firstly- I’m not sure what board to post this on, so sorry if it’s the “wrong” one.
I’ve had 4 recurrent losses last year. With my last pregnancy I was on 2x400mg of progesterone a day and aspirin but it didn’t work. All my losses have been between 6-8weeks. I’ve had all the usual blood tests. Clotting, auto immune antibodies, thyroid,21 day progesterone, AMH, ultrasound scan of my womb and ovaries etc, my husband has had a sperm analysis and it’s all come back fine. My consultant has given me antibiotics to take for inflammation on the womb and has told me for my next pregnancy to take 4x400mg of cyclogest a day, 5mg of folic acid and clexane from a bfp and aspirin from 6 weeks. I’m not pregnant again but just looking to see if this has worked for anyone else? Or any stories of hope??

It's a tricky one because you presumably neither you or your doctor know the reason for your miscarriages so they are not suggesting clexane etc in response to a diagnosis? I've had 5 miscarriages and was on progesterone and clexane from ovulation/BFP with 4 of them and it made no difference

Ultimately my miscarriages were attributed to chromosomal/poor egg quality issues but you'd only be able to know this if you did IVF or tested the POC from your miscarriages?

@ivfbeenbusy thank you for your reply. No it’s basically “just incase”. They tested my third miscarriage and I was told that there were “no concerning features found” or something along those lines were going to have Karyotyping tests done on ourselves to see if that’s the issue. But we’re pretty much being told to keep trying and not give up hope 😩

@Sallyjo27

Just bear in mind that karyotyping is only really going to identify if there is an issue with your OR partner - it's pretty rare to actually find anything and only really If you suspect a family
History of genetic disorders - it can't tell you if the embryos you make TOGETHER are chromosomally normal - you'd need to do IVF with PGS for that x

I had clexane in my successful pregnancies but that because I have factor V. Sorry I can't offer more than that