Did you have a miscarriage after a normal Harmony test?

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Hi there.

I'm 6+4 today. I plan to get the Harmony test at 10 weeks. This is pregnancy number two via IVF so we have our viability scan this Friday.

Just wondering have any of you had a miscarriage after getting a normal Harmony test result?

Basically I wonder if we can tell people our pregnancy news at 10 weeks if we get a normal Harmony test result or if the risk of miscarriage is still significant (which means we wait until our 13 week dating scan to be sure).

Thanks for any replies x

Isn't the harmony test for downs and other chromosome abnormalities?
I didn't think it was anything to do with a risk of miscarriage but may be wrong.

On the positive side, a healthy scan with heartbeat at 10 weeks means your chance of MC is very low.

Hi sel2223 yes it's for trisomies 21, 13 and 18 I think (21 being Downs). It can check for aneuploidy as well like having the wrong number of sex chromosomes (eg XXX or XXY I think). It's not for miscarriage risk. Scan will have been at 6 weeks 6 days so not sure if early scan plus test is enough reassurance.

Hoping to hear from anyone who's had a miscarriage after testing...

Never had a harmony but there will certainly be women who have had a MC after a normal result as the results aren't that relevant to miscarriage risk. Seeing a heart beat on a scan at 10 weeks is a better indicator, but even then sadly some will go on to miscarry. I felt happy sharing the news of both my pregnancies around 9-10 weeks after private scans showed viability, but it's a personal decision.

I think if your harmony test came back clear then you should feel more confidant UNLESS you have any known underlying conditions which might cause a second trimester loss - eg auto immune etc, I do know people who have still gone on to have a loss at around 16 weeks with a healthy baby eg if the placenta has suddenly failed but it's very rare

I'm 9 weeks with IVF twins and I'm
Thinking of the harmony too - is 10 weeks too early? Does it affect its accuracy? I was thinking the NIPT is more accurate? X

Yes that's true Annabel28. I just feel like 12 weeks is so far away. This nausea is bad and not something I experienced with my first pregnancy so it's hard trying to act normal while keeping a secret!

No I don't know of any underlying conditions that would increase my risk of miscarriage ivfdreaming aside from my age (39). It seems even 12 weeks pregnancy reveal can still end in sad news so there's no guarantee at any stage that things will turn out ok. Sorry to hear about your friend's loss. I was really glad I got our son's Harmony test done and it was fun finding out the sex early too. The clinic I go to start tests at 10 weeks so I'm guessing it's not too early. Harmony is a type of NIPT (non invasive prenatal testing). I haven't checked if it is suitable for a twin pregnancy so do check!

Guess no one coming back with yes they've had a miscarriage after normal Harmony is a good thing...

I had the harmony test done at Fetal Medical Centre on Harley Street. Not sure why you are worried for the MC risk, it is just a blood test. We had the 10 week scan and 12 week scan included as part of the package and I couldn't recommend them more. FMC were so professional, explained every step of the process and the results clearly, and their scans images are so much clearer than on NHS or other private cabinet we went to.

I was told that the risk of miscarriage at 10 weeks isn’t that different from 12 weeks ! Plus if you are getting the harmony test that rules out any abnormalities.

I would have no issues telling friends and family at 10 weeks .

Oh I'm not worried about the test causing miscarriage as it is non invasive DJBebe. That's great you got two scans included in the package. Must have been a bit expensive. For the test alone it was around £500 I think. Worth every penny imho.

Thanks for your reassurance MichelleOR84 I guess the only thing that worries me now is telling people after a normal Harmony test at 10 weeks then seeing birth defects on the 13 weeks enhanced scan. What a dilemma.

Thanks for your reassurance MichelleOR84 I guess the only thing that worries me now is telling people after a normal Harmony test at 10 weeks then seeing birth defects on the 13 weeks enhanced scan. What a dilemma.*

In that case then maybe it's best to wait till the 20 week scan. They still pick up anomolies on that one (which is why they do it). We waited till the 20 week scan but I had to avoid people in the last week since I was clearly showing, so there's that to consider as well.

You'll never know for certain without an amniocentesis if your baby is completely healthy, no chromosomal issues etc. You'll only have a strong indication. However, that's why the 20 week scan is so important because at 10/12 weeks you can't tell much. Not to mention miscarriages can happen for all kinds of reasons and still birth.

But the way I look at it, if anything was to happen I'd want everyone close to me around me, so I told me people after 12 weeks. Do whatever feels right OP, I don't think test results make that much difference as complications in other ways can happen. But the chances are so so low, so go for it! x

Wow Isthisfinallyit! 20 weeks. I couldn't hide it that long! I'm slim and showed my first pregnancy by 14/16 weeks I think.

Yes Danielle95lab it's a mine field. Not 100% until the baby is in your arms.

I'm hopeful that my 3D 13 week scan will be ok cause if so it's looking like that's the best time to tell friends and family. I have a friend visiting me in 9 days for a social distancing walk. Hoping my sickness improves so I can act normally without giving it away!

You should share your pregnancy news when it feels right for you - miscarriage does happen but those who you tell would be able to support you if it did.
I didn’t share my news with my extended family - who I am actually close to - until 20 weeks - lockdown helped this be possible - I’m currently 28+1. I just did what felt right for me as I had a miscarriage previously. Once you’ve told people it’s all they want to talk about so I enjoying having the news just with those who were closest to me to begin with.

That's true Prettylittlelady. Congrats - past 28 weeks you're well out of the woods! Miscarriage sucks so glad things are working out for you. One family member at least is against terminations even for heath issues so I'd feel sad telling them if I do need a termination at any point. Guess I'm just picturing worst case scenarios! Ok, gonna see what happens at the viability scan tomorrow and take it from there.

Thanks for all your replies!