They made a huge difference to me. I bought the travel sickness ones from boots.
I did indeed forget to take them off once I got to work one day, someone asked me why I was wearing travel sickness bands......
I used to put them on first thing and Wear them all day if not working. I had very noticeable tan lines! If I was at work I would take them off when I got there, put them on at lunchtime and as soon as I finished.