4 MCs, clexane next time and am scared.

[aMuminwaiting]

Hi
Well I've had four miscarriages now. The first was back in 2010, after a year of trying I lost my boy at nearly 22 weeks. Then I had the three more earlier miscarriages all quite close together. After a six month break I'm ready (as ready as I can ever be) to try again. My DH has been very good and said whenever I'm ready that's fine with him. I've had all negative test results, they don't understand why this keeps happening but have told me to try clexane injections and aspirin next time because "you've got nothing to loose". Bad choice of words.
I was on progesterone for the last two pregnancies. All it did was mask what was happening with the last. I felt like it was all going well and then went for my 12 week scan only to find the baby had died a month earlier.
Because I've had bleeds with three of the pregnancies (very heavy bleeding) I'm worried that the clexane could be dangerous. I did ask the 'blood specialist' about that but she said it won't make me bleed, if I was going to bleed anyway then it won't stop it. That's not what I was asking though. I meant will it make the bleeding worse to the point of being dangerous? She only had information on what happens if I get very close to full term. Frankly that seems as likely as winning the lottery right now so I wanted to know more about the run up to that stage.
Any advice from people who've been on it or are on it would be great. I'm nervous enough going into this all again as it is without the added worry of bleeding to death.

sadly not. That was my 6th miscarriage.
We are no longer trying for a baby.

mrsnesbit sorry that you have taken the decision to stop trying. I totally understand that and have toyed with it myself plenty of times. And my best friend almost begged me after my last suspected ectopic incident. I ignored her and am hoping against the odds that this one sticks. Which specalist have you been seeing? Hugs.

That must have been the hardest decision of your life to make mrsnesbit. Each time I swear that is it but I think that in reality I will keep going until they tell me I have zero chance. Sometimes I wish they'd just take the decision out of my hands and say no more. I know we'd adopt but until I've totally given up we won't peruse it. For me the guilt of my body killing my babies is the main reason I keep telling myself that this has to be the last time. I feel torn apart by it a lot of the time. I don't know about the rest of you but I've found that friends and family seem to react less and less the more I lose. The first time they were all shocked (for about two weeks) and then it was like he meant nothing and I was told to just try again and it would all be ok. I get really angry with my mum now who tells me it will be fine this time, you're going to get your baby. Really? Because she's said that every time. I hate how blasé everyone is. They tell me I dwell on it all too much. I doubt they'd ever get out of bed if it was them though!
So yes I'm in a terrible mood today. Another bfn, more cramps, raging hormones. I couldn't get the frying pan clean this morning and nearly ripped my DH's head off. Pass me the bloody chocolate now!!!!!!!!!

that should have been pursue.

I was at Liverpool.
I have finally accepted that there is nothing they can do to help me, there are no answers that they can give me. and that fact slapped me in the face when they told me that this is true for 80% of all reoccuring miscarriages.
Its the best decision for us, i could not go on and on losing baby after baby.

Agree about people whitewashng over it. I even had people muttering "Again?!"
I should be cradling my new baby right this minute, while complaining on here that i have forgotton to do everything with newborns. But im not.

I HATE that we have had to give up. I HATE that we will never have a sibling for my ds, i am comforted by the fact that i did absolutely nothing wrong to cause my losses. For me, that is very very important.

Good luck and ignore my negative rantngs, some days i cans ee nothing but negativity, other days the sun comes out and i am grateful for my lot.

I was on 40mg clexane, gestone, progesterone suppositories, aspirin and dexamathasone as I have raised NK cells. I now have 3 boys inc twins. There are several schools of thought about rpt mc - some practitioners add in other immunomodulators such as humira and iVIG, which aren't generally available via the NHS. MrsNesbit I'm so very sorry for your losses. I'm assuming you were under Siobhan Quenby? I can understand drawing a line under such pain but if you (or the OP or anyone else) wanted to look further, Amin Gorgy, Hassan Shehata, and George Ndwuke take private patients with rpt mc and will consider more aggressive treatments, with good results. The other v v aggressive option is ARGC, which is where we went.
The clexane is a very small dose, and so long as you leave 12 hours between the last dose and an epidural, you can give birth how you like. If there's a problem they can still do a spinal block instead - a cs isn't a given, but sone obs and haems prefer it as it helps with planning.
Very very best of luck.

Thanks BagofHolly. I've heard a lot of good things about Mr Shehata. My consultants have all been going round the houses regarding a recurrent miscarriage clinic. They just keep trying to avoid it. This will be my last try with the NHS, if I miscarry again I will get on the list for a clinic even if I have to hurt someone!
I've been a mess today. Feeling really negative and hopeless. The period cramps have been kicking in and my mood was crazy. I nearly lost it just because I couldn't get egg off the frying pan! But you've brought hope back. I've said before I'll do whatever I have to if it means getting to hold my baby. I held one of my friends twins on Friday and just felt like she should be mine. The only stronger feeling I've ever had is when I held my tiny baby boy. Asking the nurse to take him away was incredibly hard but if I didn't do it then I'd have never let them take him.

You poor darling girl! How awful.
Shehata sees NHS patients via Epsom hospital I think. I think it's worth trying to become your own expert patient, and I found Alan Beer's "is my body baby friendly?" was a really good read and well worth a look. X

Good post BagofHolly.

I was under Amin Gorgy and he was fantastic. 1st go with him we got and stayed pregnant after 7 years and 5 mcs (and an ectopic).

Also recommend the Beer book (though I skipped all the tricky chapters despite having a PhD in Science!)

I read Miscarriage: What every Woman needs to know by lesley Regan but to be honest I didn't find that one very helpful. I did read a lot after my last loss and looked up tons of stuff on the internet but when I saw the consultant she was really awful and just slammed down every question I had. She also said she didn't think immune system disorders had anything to do with miscarriage and looked me up and down before saying " a lot of women find losing weight and stopping smoking helps". I could maybe lose half a stone and have never smoked in my life. I've also been t-total since beginning this nightmare four years ago. I have found the consultants to be on the whole really obnoxious and totally unsympathetic. When i get frustrates because they keep missing opportunities to test my babies by mistaking bits of mucus or blood clot for the foetuses I just get shrugs and well it's unfortunate. I was sitting in a small room having had to with with loads of pregnant women (one of whom was morbidly obese and one of whom had been puffing away outside on a fag) after the last miscarriage and was being told "ahh I see here that Dr Bitchface (not real name but really should be) told you about the benefits of losing some weight". And there was a poster about abuse to staff not being tolerated and I though what about abuse to patients?! I just want to be treated like a human.

that should have been: I was sitting in a small room having had to sit with loads of pregnant women

Ugh don't get me started on Lesley Regan. I'm sure she's an excellent scientist/researcher, but that's her focus, NOT getting pregnant women to stay that way. I think it's well worth looking at the approaches taken by private practitioners who are able to a) use some therapies off licence in a patient group that's very hard to do clinical trials in, and b) produce replicable results in women who have had multiple losses.
Have hope. There are many paths left to try. X

amuminwaiting really interested in immume disorders.I am coeliac and I have always been convinced that this may be a factor in my body attacking anything in me. Prof R thinks all about the clotting. I am interested in finding more about killer cells - must get the google finger working.

It makes me happy to know that there are people out understand how I feel but sad that there are so many of us that have to keep going through this shit. I try to just numb myself to it but sometimes that is impossible. I know if this one fails I have to think about throwing the towel in. And that is the worst thought of all. I have a scan tomorrow to check it is in the right place this time. Fingers crossed.

Midgetm, I so hope that things work out for you. I found a good place to start is Alan Beer's repromed website, and the book I mentioned earlier. Once you've got your head round it the treatment is relatively cheap and usually straightforward. Blood thinners and various immunosuppressants, and some additional progesterone. That's all. In our case we ALSO needed ICSI but we got there in the end.
Tell you something, I've been kn this journey for a few years now, and have read forum after forum and met people through my clinic and also through the HFEA. In all that time, once women had actually got in front of the Big Names - Taranissi (Argc) Shehata, Gorgy etc, all but two women made it to motherhood. One girl had additional problems with her cervix which were insurmountable, the other had 7 cycles of IVF and went on to adopt. In EVERY other woman I cam think of, who got the proper help, they got there in the end. I'm not trying to give false hope. That would be terribly cruel, but I AM saying that the NHS isn't the only path. x

bagofholly I will def look at that. I have no problem getting pregnant so if I can find someone who can keep it in me I should be fine! I have an arsenal of heperin and progesterone downstairs from a previous attempt and stopping myself inhaling the lot. I may give the prof another crack of the whip and then look these guys up. Thanks for your advice.

I started my period in the middle of the night. That coupled with it being two years tomorrow that my first baby died means I am a wreck today. Can't stop crying and my DH is dealing with that by ignoring me. I really want a hug.

Here is a hug. It is a virtual one but it is heart felt and it is the thought that counts. words are pretty shit in these circumstances but i will try some anyway. Throw them away if they do not help. You have been through so much but you have survived and this feeling will pass. Sadness does ease over time, it just doesnt always feel like it. Just in case the words did t help here is another hug. XX

Hi muninwaiting, I have had 3 MCs and am currently pregnant (9+6). I'm with a private clinic and they put me on clexane pretty much straight away. I also have a high natural killer cell count so am having treatment for that too. As well as progesterone supplements and steroids.

Good luck with it all

Ten minutes into walking my dog and in the middle of town I get a searing pain and feel the flooding. Through a night towel, two pairs of pants and thick tights. Isn't it wonderful being a woman?!

Sometimes it is a right bitch.

well I've got my positive test and have spent three days trying to get an appointment for the blood specialists. The out of hours GP gave me four days worth of clexane but I'll be out before I get an appointment. Even my GP won't get back to me. As if this wasn't scary enough the medical professionals are set to give me a breakdown!
PS I had the faintest second line on an internet cheapie Saturday so got the clear blue digital which put me t 3-4 weeks. I've done the internet cheapies each morning since and they're not getting darker. Is this a bad sign?

Are any of you still there? I need some reassurance. Got my positive results Saturday, brown when I wiped yesterday and this morning and it's not pink. I don't want to give up but it doesn't look good. Any positive stories out there?

Hello,
You poor thing. I had a similar situation, at 4 weeks I had brown spotting for 4 days, one wipe of red but no cramps. I thought it was going to end the same way as the others. I was on clexane this time and in despair.
In my case it was just implantation.

Do NOT stop taking the clexane (which was my first question to the consultant) as strange as it seems, it helps with implantation even though your instinct is to stop if you are bleeding.

I had serial HCG done and it was more than doubling every 48hrs all throughout the spotting which was very reassuring. Can you ask for similar? It will give you a clear indication of what is happening at this stage (I think you are too early for a scan?)

I am not out of woods yet, 8 weeks and have a scan next week (wibble)
but I did think it was game over at 4 weeks and all was well at that stage.
Best of luck!

Thanks so much. I've felt low today but at the same time stronger than other times. I know I;m doing EVERYTHING I can. It's going from brown to pink and just now I had what looked like a clot but the size of a pin head. I'm really hoping this is a late implantation. I did my second clearblue test today and it still said 1-2 weeks which puts me at 3-4 weeks pregnant. I took it apart hoping the lines would be much darker than Saturdays but they are the same. In my first pregnancy I had a light bleed for a week and thought my period was about to kick in but it never got heavier and instead I found out I was pregnant. I got to 22weeks and 5 days with him. I didn't have it with the others and they were all quite early miscarriages. I hope this is a good sign even though it's scaring me!
I thought they'd check my HCG levels but so far no one's been keen to do anything. Each time I think I'll get more help but they never live up to my expectations. They didn't even tell me that the sharps box lid shouldn't be completely shut until it's full. They all assume I know everything having never used things or done things before.
I'll keep my fingers crossed for you. It's all so frightening isn't it.