Amnesty
WWF
My SIL and I are currently in the process of setting up a charitable trust to raise money for more research into the kind of cancer my brother had (sarcoma - he specifically had mesenchymal chondrosarcoma). It's very rare and not much understood, extremely difficult to treat and often difficult to diagnose - with my brother there were no lumps, no blood, no obvious symptoms apart from worsening backache, sciatica and sometimes incontinence. His cancer was only diagnosed when he had to have an emergency spinal decompression and they found that the cause was an enormous tumour that was dissolving his spine. It had already spread to his lungs and elsewhere by then. MC doesn't respond well to chemo or radio, and you can only operate so much. He died just over two years after diagnosis, three weeks after his first wedding anniversary.
So now the vast majority of my 'charity cash' goes towards that, including DD and penny jar. We're currently chasing charitable status and trying to get a website set up, and once that's done we can start fundraising properly.