Was absolutely terrified of spiders, at one point would pass out in terror when some shitbiscuit threw one at me if confronted with one.
Then, through unrelated reasons, I had a nervous breakdown type thing all over our bedroom floor, and ended up on anti-depressants. Now, these pills are also used to treat OCD, PTSD etc, so I would presume phobias are maybe in the same part of the brain or something, I don't know, but one day, there was a reasonably size of a fecking dinnerplate sized spider on the wall above my bed, and instead of freaking out, I just said "Oh bog off you bastard" and went to sleep.
Then I found myself picking them off the walls and putting them outside (much to dad's horror), and so, one day, to see if I really was cured , I got someone with a pet tarantula to come round, and yes, I managed to hold him/her/it. Admittedly I was wearing elbow-length velvet gloves but A) Rome wasn't built in a day, and B) I would not have even thought about doing that a year or so previously.
I have since come off the (CR)happy pills, as the side effects got worse than the original illness, BUT, I am still able to function around eight-legged creatures. NLP also helped - imagine the spider is dressed as a clown, complete with eight little clown shoes - and then just laugh at them and their knobbish ways... :o